TITLE

A historical perspective on leptin

AUTHOR(S)
Coleman, Douglas L.
PUB. DATE
October 2010
SOURCE
Nature Medicine;Oct2010, Vol. 16 Issue 10, p1097
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
In this article, the author discusses aspects of the connections between his earlier parabiosis experiments of mutant obese mice and the satiety factor leptin. The author states that the leptin, which controls adipose tissues mass in order to modulate appetite, has changed the prevailing theory on obesity. Furthermore, it says that although leptin replacement therapy transforms leptin deficient obese persons into leaner individuals, obese humans with normal genes for leptin are leptin resistant.
ACCESSION #
54301421

 

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