TITLE

A stimulating way to improve T cell responses to poxvirus-vectored vaccines

AUTHOR(S)
Isaacs, Stuart N.
PUB. DATE
January 2011
SOURCE
Journal of Clinical Investigation;Jan2011, Vol. 121 Issue 1, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Vaccines remain one of the most cost-effective public health measures. Despite ongoing efforts, protective vaccines against cancer and many infectious diseases, including malaria, tuberculosis, and HIV/AIDS, are still not in hand. Most investigators believe that to succeed against these difficult targets, vaccines that generate potent T cell responses are needed. In this issue of the JCI, Salek-Ardakani et al. show how the relative virulence of a virus/vaccine vector affects the memory CD8+ T cells generated and how the response may be enhanced. The work has important implications for the development of future vaccines that aim to trigger CD8+ T cell responses.
ACCESSION #
58077542

 

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