TITLE

Bone-adiposity cross-talk: implications for pediatric obesity. A narrative review of literature

AUTHOR(S)
Chaplais, Elodie; Thivel, David; Greene, David; Dutheil, Frederic; Duche, Pascale; Naughton, Geraldine; Courteix, Daniel
PUB. DATE
November 2015
SOURCE
Journal of Bone & Mineral Metabolism;Nov2015, Vol. 33 Issue 6, p592
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body's responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.
ACCESSION #
110527811

 

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