Progressive Multifocal Leukoencephalopathy – Progress Made and Lessons Relearned

Greenlee, John E.
May 1998
New England Journal of Medicine;05/07/98, Vol. 338 Issue 19, p1378
Academic Journal
This editorial discusses multifocal leukoencephalopathy, an opportunistic demyelinating infection caused by the nonpathogenic papovavirus known as JC virus. The disease was initially identified as a rare complication of chronic lymphocytic leukemia and Hodgkin's disease. A discussion is presented about the increase in the number of patients with progressive multifocal leukoencephalopathy due to AIDS that has provided both impetus and a sufficient number of patients for organized therapeutic trials.


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