TITLE

Interpreting Surgical Trials With Subjective Outcomes

AUTHOR(S)
Flum, David R.
PUB. DATE
November 2006
SOURCE
JAMA: Journal of the American Medical Association;11/22/2006, Vol. 296 Issue 20, p2483
SOURCE TYPE
Academic Journal
DOC. TYPE
Editorial
ABSTRACT
The article presents an editorial about how to interpret results from surgical trials. The authors remark that it is important to distinguish between the effect of the intervention from the effect of the patient's expectation of the intervention when analyzing subjective outcomes in health care interventions. To avoid the placebo effect, it is necessary to ensure that patients do not know which treatment they are receiving. This randomization technique is not often practiced in surgical trials. The ethics underlying sham-controlled studies are discussed.
ACCESSION #
23178031

 

Related Articles

  • Developing a survey of barriers and facilitators to recruitment in randomized controlled trials. Kaur, Geetinder; Smyth, Rosalind L.; Williamson, Paula // Trials;2012, Vol. 13 Issue 1, p1 

    Background: Recruitment to randomized controlled trials is known to be challenging. It is important to understand and identify predictors of good or poor accrual to a clinical trial so that appropriate strategies can be put in place to overcome these problems and facilitate successful trial...

  • Experiences with the Execution of Intercultural, Intercontinental Trials - Part I. Barnett, H. J. M. // Canadian Journal of Neurological Sciences;May2013, Vol. 40 Issue 3, p324 

    Large scale, international clinical trials are formidable challenges, but they are the most effective means of answering important clinical questions in a definitive, generalizable manner. They require adequate funding and must be rigorously conducted. Much can be gleaned from such studies,...

  • Study to Test Exercise in Heart Failure Patients.  // IDEA Fitness Journal;May2007, Vol. 4 Issue 5, p15 

    This article announces that a randomized clinical trial of exercise training is underway which will involve 83 sites that will test 3,000 people to find out whether exercise is good for hearth failure patients. It says that health and fitness promoters may benefit from this undertaking. Delane...

  • No differences in outcomes between cemented and uncemented acetabular components after 12–14 years: results from a randomized controlled trial comparing Duraloc with Charnley cups.  // Journal of Orthopaedics & Traumatology;Mar2010, Vol. 11 Issue 1, p37 

    The article presents a study on the long-term clinical and radiographic outcome and component survival in a randomized controlled trial. A total of 215 patients were allocated to receive a cemented Charnley cup or uncemented Duraloc 1200 cup. After ten years, there is no statistically...

  • Uptake of novel medical therapies in the general population. Booth, C. M.; Rapoport, B. // Current Oncology;Jun2011, Vol. 18 Issue 3, p105 

    The author reflects on the effectiveness of randomized controlled trial (RCT) in establishing the efficacy of new medical therapies. He cites the approval of the clinicians regarding the validity of RCT to understand how the result may relate to the patient care and outcomes in medical...

  • Clinical trials exclude patients for questionable reasons.  // Patient Care for the Nurse Practitioner;Apr2007, Vol. 10 Issue 4, p11 

    The article discusses research being done on the selection of patients for randomized controlled clinical trials. It references a study by H. G. Van Spall and colleagues, published in the 2007 issue of "Journal of the American Medical Association." The study analyzed the nature and extent of...

  • Human-subjects research: Trial and error. Ledford, Heidi // Nature;8/2/2007 Supplement, Vol. 448 Issue 7153, p530 

    The article focuses on the efforts of researchers to come up with alternatives to institutional review boards (IRBs) that would determine if a proposed research is ethically sound. It mentions the problems encountered by most researchers in many countries due to the presence of a complex network...

  • The challenges faced in the design, conduct and analysis of surgical randomised controlled trials. Cook, Jonathan A. // Trials;2009, Vol. 10, p1 

    Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the evaluation of surgical interventions....

  • Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design. Relton, Clare; Torgerson, David; O'Cathain, Alicia; Nicholl, Jon // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;5/1/2010, Vol. 340 Issue 7753, p963 

    The "cohort multiple randomised controlled trial" (cmRCT) design tackles some of the problems associated with pragmatic trial designs, such as recruitment. The cmRCT design has several innovative features: a large observational cohort of patients is recruited and used as a multiple trials...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics