The use of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of thyroid lesions

Casal, Roberto F.; Phan, Mimi N.; Keshava, Keerthana; Garcia, Jose M.; Grosu, Horiana; Lazarus, D. Ray; Iribarren, Juan; Rosen, Daniel G.
December 2014
BMC Endocrine Disorders;2014, Vol. 14 Issue 1, p20
Academic Journal
Background Non-palpable thyroid nodules can be difficult to access by conventional ultrasound-guided fine needle aspiration, particularly when they are intrathoracic. Many of these patients are subject to multiple follow up scans or invasive diagnostic procedures such as mediastinoscopy or surgical resection. We aim to describe the feasibility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for diagnosis of thyroid lesions. Methods All EBUS-TBNA performed at our institutions from February 2010 to February 2013 were screened, and those in which a thyroid biopsy was performed were reviewed. Results We identified 12 cases of EBUS-TBNA thyroid biopsy. Nine patients had an indication for EBUS in addition to their thyroid lesions. The median age was 64 years (range 44 to 84 years), and 10 patients were male. Median lesion size was 22.5 mm (range, 10 to 43 mm). Five lesions were strictly intrathoracic. All cases were sampled with a 22G needle and rapid on-site cytologic examination. Adequate samples were obtained in all 12 cases. Malignancy was identified in 3 of the 12 patients (metastatic breast adenocarcinoma, large B-cell lymphoma, and metastatic lung adenocarcinoma). The remaining 9 samples were deemed to be benign nodules. Seven of these were confirmed by clinical follow-up (n = 3), biopsies (n = 3), or surgery (n = 1). There were no EBUS-related complications. Conclusions EBUS-TBNA might be a safe and effective alternative for sampling thyroid lesions, particularly useful for those located below the thoracic inlet. Further prospective studies are required to compare its diagnostic yield and safety profile with standard techniques.


Related Articles

  • Routine Ultrasound-Guided Aspiration Cytology for Evaluation of Palpable Thyroid Nodules in an Endemic Area: Is It Justified? Muruganandham, K.; Sistla, Sarath Chandra; Elangovan, S.; Verma, Surendra Kumar // Journal of Otolaryngology -- Head & Neck Surgery;Apr2009, Vol. 38 Issue 2, p222 

    Purpose: To prospectively evaluate the efficacy of routine ultrasound-guided fine-needle aspiration cytology (FNAC) of thyroid nodules in an endemic area and to analyze the factors influencing it. Methods: Patients with thyroid nodules were randomly subjected to either conventional...

  • Comparison of Folicular, Hurthle Cell Neoplasm and Oncocytic Changes Diagnosed by Thyroid Fine Needle Aspiration with Postoperative Histopathological Results. Aydın, Yusuf; Turgut, Mehmet; Erkan, Melih Engin; Özaydın, İsmet; Oktay, Murat; Kutlucan, Ali; Önder, Elif; Gür, Mücahit; Sav, Tansu // Turkish Journal of Endocrinology & Metabolism;Mar2014, Vol. 18 Issue 1, p5 

    Purpose: Main diagnostic method of thyroid nodules is fine needle aspiration biopsy (FNAB), but sensitivity of this method in the evaluation of follicular lesions is low. We reevaluated patients who underwent operation with FNAB reports of follicular neoplasm, Hurthle cell neoplasm and oncocytic...

  • Thyroid Cytopathology Reporting by the Bethesda System: A Two-Year Prospective Study in an Academic Institution. Mehra, Payal; Verma, Anand Kumar // Pathology Research International;1/22/2015, Vol. 2015, p1 

    Background. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has attempted to standardize reporting and cytological criteria in aspiration smears. Aims. The objective of this study was to analyze the thyroid cytology smears by TBSRTC, to determine the distribution of diagnostic...

  • The role of repeat fine needle aspiration in the management of indeterminate thyroid nodules. Jooya, Alborz; Saliba, Joe; Blackburn, Audrey; Tamilia, Michael; Hier, Michael P.; Mlynarek, Alex; Forest, Véronique-Isabelle; Rochon, Louise; Florea, Anca; Hangjun Wang; Payne, Richard J. // Journal of Otolaryngology -- Head & Neck Surgery;10/18/2016, Vol. 45, p1 

    Background: Management decisions are not straightforward when the Ultrasound Guided Fine Needle Aspiration (USFNA) demonstrates a Bethesda score of either category III or IV, and a diagnostic hemi-thyroidectomy or a repeat USFNA (r-USFNA) could be performed. The aim of this study is to assess...

  • Preoperative thyroid ultrasonography and fine-needle aspiration cytology in ectopic thyroid. Chih-Yuan Wang; Tien-Chun Chang // American Surgeon;Dec1995, Vol. 61 Issue 12, p1029 

    Evaluates ectopic thyroid development through thyroid ultrasonography and fine-needle aspiration (FNA) cytology. Rarity; Surgery as treatment of choice for the management of lesions; Permanent hypothyroidism as effect of surgery; Importance of thyroid ultrasonography.

  • The Mcgill thyroid nodule score - does it help with indeterminate thyroid nodules? Varshney, Rickul; Forest, Veronique-Isabelle; Mascarella, Marco A.; Zawawi, Faisal; Rochon, Louise; Hier, Michael P.; Mlynarek, Alex; Tamilia, Michael; Payne, Richard J. // Journal of Otolaryngology -- Head & Neck Surgery;2015, Vol. 44 Issue 1, p1 

    Background: Ultrasound guided fine-needle aspiration (USFNA) biopsy of thyroid nodules often gives a result of indeterminate pathology, placing thyroid specialists in difficult management situations. The aim of this study is to evaluate the incidence of malignancy in patients undergoing surgery...

  • Is Follow-up BRAFV600E Mutation Analysis Helpful in the Differential Diagnosis of Thyroid Nodules with Negative Results on Initial Analysis? Yoon, Jung Hyun; Kim, Eun-Kyung; Moon, Hee Jung; Kwak, Jin Young // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Background: We evaluated the usefulness of follow-up BRAFV600E mutation analysis using ultrasonography-guided fine-needle aspiration (US-FNA) in diagnosis of thyroid nodules showing negative BRAFV600E mutation on prior analysis. Methodology/Principal Finding: A total of 49 patients (men:...

  • Dependence of Thyroid Sonographic Markers of Malignancy and Its Influence on the Diagnostic Value of Sonographic Findings. Woliński, Kosma; Stangierski, Adam; Szczepanek-Parulska, Ewelina; Gurgul, Edyta; Ruchała, Marek // BioMed Research International;1/22/2015, Vol. 2015, p1 

    Introduction. Thyroid nodules constitute frequent medical condition. Ultrasonographic (US) examination remains the basis in the diagnostics of nodular goiter and selection of the suspected ones requiring fine-needle aspiration biopsy (FNAB). The aim of this study was to evaluate if the features...

  • Value of Repeating a Nondiagnostic Thyroid Fine-Needle Aspiration Biopsy. Israel Orija; Maria Piñeyro; Charles Biscotti; S. Reddy; Amir Hamrahian // Endocrine Practice;Nov2007, Vol. 13 Issue 7, p735 

    Objective: To assess the value of repeating a biopsy when the initial thyroid fine-needle aspiration (FNA) biopsy is nondiagnostic.Methods: Between 1990 and 2003, 4,311 thyroid FNAs were performed at the Cleveland Clinic Foundation, of which 220 (5%) were nondiagnostic. Among 189 patients whose...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics