Comprehensive educational plan for patients with epilepsy and comorbidity (EDU-COM): a pragmatic randomised trial

Beretta, Simone; Beghi, Ettore; Messina, Paolo; Gerardi, Francesca; Pescini, Francesca; La Licata, Andrea; Specchio, Luigi; Ferrara, Mariangela; Canevini, Maria Paola; Turner, Katherine; La Briola, Francesca; Franceschetti, Silvana; Binelli, Simona; Giglioli, Isabella; Galimberti, Carlo Andrea; Fattore, Cinzia; Zaccara, Gaetano; Tramacere, Luciana; Sasanelli, Francesco; Pirovano, Marta
August 2014
Journal of Neurology, Neurosurgery & Psychiatry;Aug2014, Vol. 85 Issue 8, p887
Academic Journal
Background: The impact of educational strategies in the management of adverse treatment effects and drug interactions in adult patients with epilepsy with comorbidities remains undetermined. Background: The impact of educational strategies in the management of adverse treatment effects and drug interactions in adult patients with epilepsy with comorbidities remains undetermined. Methods: 174 adult patients with epilepsy with chronic comorbidities, multiple-drug therapy and reporting at least one adverse treatment effect and/or drug interaction at study entry were randomly assigned to the educational plan or usual care. The primary endpoint was the number of patients becoming free from adverse treatment events and/or drug interactions after a 6- month follow-up. The number of adverse treatment events and drug interactions, health-related quality of life (HRQOL) summary score changes and the monetary costs of medical contacts and drugs were assessed as secondary outcomes. Results: The primary endpoint was met by 44.0% of patients receiving the educational plan versus 28.9% of those on usual care (p=0.0399). The control group reported a significantly higher risk not to meet successfully the primary endpoint at the end of the study: OR (95% CI) of 2.29 (1.03 to 5.09). A separate analysis on drug adverse effects and drug interactions showed that the latter were more sensitive to the effect of educational treatment. Quality of life and costs were not significantly different in the two groups. Conclusions A patient-tailored educational strategy is effective in reducing drug-related problems (particularly drug interactions) in epilepsy patients with chronic comorbidities, without adding significant monetary costs.


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