Approach to assessing determinants of glucose homeostasis in the conscious mouse

Hughey, Curtis; Wasserman, David; Lee-Young, Robert; Lantier, Louise
October 2014
Mammalian Genome;Oct2014, Vol. 25 Issue 9/10, p522
Academic Journal
Obesity and type 2 diabetes lessen the quality of life of those afflicted and place considerable burden on the healthcare system. Furthermore, the detrimental impact of these pathologies is expected to persist or even worsen. Diabetes is characterized by impaired insulin action and glucose homeostasis. This has led to a rapid increase in the number of mouse models of metabolic disease being used in the basic sciences to assist in facilitating a greater understanding of the metabolic dysregulation associated with obesity and diabetes, the identification of therapeutic targets, and the discovery of effective treatments. This review briefly describes the most frequently utilized models of metabolic disease. A presentation of standard methods and technologies on the horizon for assessing metabolic phenotypes in mice, with particular emphasis on glucose handling and energy balance, is provided. The article also addresses issues related to study design, selection and execution of metabolic tests of glucose metabolism, the presentation of data, and interpretation of results.


Related Articles

  • Vitamin D Deficiency Linked More Closely to Diabetes Than Obesity.  // Nutraceuticals World;Apr2015, Vol. 18 Issue 3, p73 

    The article discusses the highlights of a study published in the "Journal of Clinical Endocrinology and Metabolism" to clarify the connection between vitamin D, obesity and diabetes, and mentions topics including health benefits of vitamin D, vitamin D biomarkers, and glucose metabolism disorders.

  • A novel long term short interval physical activity regime improves body composition in mice. Goh, Jorming; Ladiges, Warren C. // BMC Research Notes;2013, Vol. 6 Issue 1, p1 

    Background: Exercise training (ET) and physical activity (PA) offer obvious health benefits in regular participants. In pre-clinical animal models, treadmills and running wheels are the models of choice for intervention studies using ET and PA. However, the frequency and duration necessary for...

  • Metabolic disease: Obesity-associated mutations. Pola, Carolina // Nature Medicine;Dec2013, Vol. 19 Issue 12, p1582 

    The article reports the effect of kinase suppressor of Ras 2 (KSR2) in maintaining the homeostasis and glucose tolerance associated with obesity and impaired glucose metabolism in humans.

  • A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in longitudinal studies in mice. van Dijk, T. H.; Laskewitz, A. J.; Grefhorst, A.; Boer, T. S.; Bloks, V. W.; Kuipers, F.; Groen, K.; Reijngoud, D. J. // Laboratory Animals;Apr2013, Vol. 47 Issue 2, p79 

    The aetiology of insulin resistance is still an enigma. Mouse models are frequently employed to study the underlying pathology. The most commonly used methods to monitor insulin resistance are the HOMA-IR, glucose or insulin tolerance tests and the hyperinsulinemic euglycaemic clamp (HIEC)....

  • Short term outcome of congenital hyperinsulinism: case series. Song Hai Lim; Hong, Janet Y. H.; Fuziah, M. Z.; Flanagan, S.; Ellard, S.; Hussain, K. // International Journal of Pediatric Endocrinology;2013, Vol. 2013 Issue Suppl 1, p1 

    An abstract of the study "Short Term Outcome of Congenital Hyperinsulinism: Case Series" is presented.

  • Characterization of Former Gestational Diabetes Mellitus:Prognostic, Therapeutic, and Predictive Aspects. Tura, Andrea; Kautzky-Willer, Alexandra; Di Cianni, Graziano; Yogev, Yariv // International Journal of Endocrinology;2012, p1 

    In this article, the authors discuss various articles on pathophysiology of lipid and glucose metabolism in women with prior history of gestational diabetes mellitus, risk of developing type 2 diabetes and cardiovascular complications published in this issue of the periodical.

  • In the Long Run. ABERLIN, MARY BETH // Scientist;Dec2012, Vol. 26 Issue 12, p12 

    The article introduces topics within the issue that include fat's immune sentinels, metabolism and the brain and the Top 10 Innovations 2012.

  • The role of gastrointestinal factors in glucose metabolism in patients with ESRD: in need of a critical appraisal of data. Kirmizis, Dimitrios A // Kidney International;Jan2014, Vol. 85 Issue 1, p211 

    A letter to the editor is presented in response to the article "Gastrointestinal factors contribute to glucometabolic disturbances in nondiabetic patients with end-stage renal disease," by T. Idorn and colleagues in the 2013 issue.

  • Prednisolone.  // Reactions Weekly;Mar2015, Vol. 1543 Issue 1, p182 

    The article presents a case study of a 51-year-old woman who developed steroid-induced hyperglycaemia after receiving prednisolone treatment for pyoderma gangrenosum.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics