TITLE

Reversal of Obesity and Metabolic Disorders by Exercise in High-Fat Diet-Induced Obese C57BL/6 mice

AUTHOR(S)
Mahmud, Israa Ali; Al-Domi, Hayder Abdullah
PUB. DATE
September 2014
SOURCE
Jordan Journal of Agricultural Sciences;2014, Vol. 10 Issue 3, p426
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The current study was undertaken to examine whether 13 weeks of moderate aerobic exercise performed in the fed-state could reverse metabolic disorders associated with obesity in a C57BL/6 female mice fed diets high in saturated or unsaturated fats. Thirty one, five-weeks-old C57BL/6 female mice were allocated into three groups: normal fat diet group (NFD-Control) (10% Kcal fat), high saturated fat diet group (HSFD) (45% Kcal fat), and high unsaturated fat diet group (HUSFD) (45% Kcal fat). Mice were kept on such diets for 13 weeks. Exercise regimen was then undertaken. Mice given high fat diets were subdivided into two subgroups; sedentary or exercise for 13 weeks. Mice in the control group continued on the same diet without exercise treatment. Serum levels of glucose and lipid profile as well as plasma levels of glucagon-like peptide-1 (GLP-1) were analyzed after 13 weeks of diet induction, and at the end of the study. Intraperitoneal glucose tolerance tests were carried out after 12 weeks of the diet induction, and at THE 25TH week of the study. Findings of the present study indicated that hyperglycemia (P<0.001), hypercholesterolemia (P<0.01), and hypertriglyceridemia (P<0.05) were clearly observed in mice fed either HSFD or HUSFD for 13 weeks compared to that in NFD group, whereas serum levels of GLP-1 in both groups were significantly reduced (P<0.001). Mice in HFD groups gained significantly more in body weight than that in NFD group and became glucose intolerant (P<0.001). Exercise treatment for 13 weeks decreased hypertriglyceridemia (P<0.01) and hyperglycemia (P<0.001) observed in sedentary groups, and significantly reduced body mass index (BMI) (P<0.001) and feed efficiency (P<0.05), while significantly increased plasma levels of GLP-1 and improved glucose intolerance (19,155±305 and 16,852.5±725 mg/ dL. 120 min; respectively, P<0.01) in both HSFD- and HUSFD-fed mice. Exercise had no effect (P>0.05) on serum levels of total cholesterol (TC) and high density lipoprotein (HDL) in mice fed HFD. Exercise reverses obesity and metabolic disorders that results from long-term feeding of HFD without the need for dietary modification; these beneficial effects of exercise might be mediated by a significant increase in plasma GLP-1 levels following weight loss. This study therefore supports that exercise is an effective treatment for obesity.
ACCESSION #
98172341

 

Related Articles

  • The Association Between Rate of Initial Weight Loss and Long-Term Success in Obesity Treatment: Does Slow and Steady Win the Race? Nackers, Lisa; Ross, Kathryn; Perri, Michael // International Journal of Behavioral Medicine;Sep2010, Vol. 17 Issue 3, p161 

    Controversy exists regarding the optimal rate of weight loss for long-term weight management success. This study examined whether gradual initial weight loss was associated with greater long-term weight reduction than rapid initial loss. Groups were drawn from participants in the TOURS trial,...

  • Core body temperature in obesity. Heikens, Marc J.; Gorback, Alexander M.; Eden, Henry S.; Savastano, David M.; Chen, Kong Y.; Skarulis, Monica C.; Yanovski, Jack A. // American Journal of Clinical Nutrition;May2011, Vol. 93 Issue 5, p963 

    Background: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. Objective: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. Design: In study 1,...

  • The importance of community consultation and social support in adhering to an obesity reduction program: results from the Healthy Weights Initiative. Lemstra, Mark; Rogers, Marla R. // Patient Preference & Adherence;2015, Vol. 9, p1473 

    Background: Few community-based obesity reduction programs have been evaluated. After 153 community consultations, the City of Moose Jaw, SK, Canada, decided to initiate a free comprehensive program. The initiative included 71 letters of support from the Mayor, every family physician,...

  • A dose—response relation between aerobic exercise and visceral fat reduction: systematic review of clinical trials. Ohkawara, K.; Tanaka, S.; Miyachi, M.; Ishikawa-Takata, K.; Tabata, I. // International Journal of Obesity;Dec2007, Vol. 31 Issue 12, p1786 

    Objective:It has been suggested that exercise has preferential effects on visceral fat reduction. However, the dose–response effect remains unclear because of limited evidence from individual studies. The purpose of this study was to systematically review the current literature to...

  • Effects of aerobic exercise and obesity phenotype on abdominal fat reduction in response to weight loss. Okura, T.; Nakata, Y.; Lee, D. J.; Ohkawara, K.; Tanaka, K. // International Journal of Obesity;Oct2005, Vol. 29 Issue 10, p1259 

    Objective: To test the effects on abdominal fat reduction of adding aerobic exercise training to a diet program and obesity phenotype in response to weight loss.Design: A prospective clinical trial with a 14-week weight-loss intervention design.Setting and...

  • Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity. Ozcelik, Oguz; Ozkan, Yusuf; Algul, Sermin; Colak, Ramis // Patient Preference & Adherence;Jul2015, Vol. 9, p999 

    Objective: The aim of this study was to determine and compare the effects of weight loss achieved through orlistat therapy alone or a combination of orlistat and an aerobic exercise training program on aerobic fitness and body composition in obese females. Methods: Twenty-eight obese patients...

  • DESIGN YOUR OWN FITNESS PLAN. Peden, Lauren David // Essence (Time Inc.);Mar2003, Vol. 33 Issue 11, p82 

    Provides information on aerobic exercises for loosing weight. Recommended cardiovascular exercise; Routines of strength training; Details of flexibility stretches.

  • Fat-burning news. Lewis, Linda // Shape;Mar2002, Vol. 21 Issue 7, p54 

    Presents findings on cardio workouts by the American College of Sports. Benefits of doing intermittent cardio; Method of doing step aerobics to burn more calories; Frequency of aerobic workouts per week for less body fat.

  • Class action. Banados, Lisa // Shape;Jan2001, Vol. 20 Issue 5, p76 

    Relates the author's experience of success in weight loss. Keeping a journal of goals and foods eaten; Participation in an aerobics class; Support from husband and kids. INSET: Maintenance tips..

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics