TITLE

Fighting Fat With Fat: Brown Adipose Tissue

AUTHOR(S)
Panda, Suchismita; Mangaraj, Manaswini
PUB. DATE
October 2014
SOURCE
International Journal of Biological & Medical Research;2014, Vol. 5 Issue 3, p4382
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Obesity is the most common metabolic disorder that has become a global problem. The serious clinical problems associated with obesity include an increased risk for type 2 diabetes mellitus, atherosclerosis and cancer. Understanding the origin and development of adipocyte and excess adipose tissue resulting from positive energy balance are critical to analysis and treatment of obesity. The calorie burning brown fat and inducible brown fat like adipocyte known as beige fat in adults might prove useful to play a role in fighting against obesity and reducing the metabolic diseases. Many genes, the transcriptional regulators and factors, that regulate brown and beige adipocyte biology have now been identified providing a variety of therapeutic targets for metabolic diseases.
ACCESSION #
97741625

 

Related Articles

  • Lifestyle Modification in the Treatment of Obesity: An Educational Challenge and Opportunity. Jones, L. R.; Wilson, C. I.; Wadden, T. A. // Clinical Pharmacology & Therapeutics;May2007, Vol. 81 Issue 5, p776 

    As many as two-thirds of adults in developed nations are overweight (body mass index (BMI)=25.0–29.9 kg/m2) or obese (BMI 30 kg/m2),1 and many of these individuals suffer from weight-related comorbidities such as hypertension, hyperlipidemia, and type II diabetes.2 On a more...

  • Controversias en el diagnóstico del síndrome metabólico en pob aciones pediátr cas. Arjona-Villicañ, Ruy David; Gómez-Díiaz, Rita Angélica; Aguilar-Salinas, Carlos Alberto // Boletin Medico del Hospital Infantil de Mexico (Departamento de ;nov/dic2008, Vol. 65 Issue 6, p488 

    The metabolic syndrome is a clinical concept which incorporates the phenotypic expression of intra-abdominal fat and insulin resistance under a single diagnosis. The main end points of the metabolic syndrome are well known, namely type 2 diabetes mellitus and atherosclerosis. The prevalence of...

  • Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis. Kaneto, Hideaki; Katakami, Naoto; Matsuhisa, Munehide; Matsuoka, Taka-aki // Mediators of Inflammation;2010, Vol. 2010, p1 

    Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic β-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate...

  • Intimal redox stress: Accelerated atherosclerosis in metabolic syndrome and type 2 diabetes mellitus. Atheroscleropathy. Hayden, Melvin R.; Tyagi, Suresh C. // Cardiovascular Diabetology;2002, Vol. 1, p3 

    Metabolic syndrome, insulin resistance, prediabetes, and overt type 2 diabetes mellitus are associated with an accelerated atherosclerosis (atheroscleropathy). This quartet is also associated with multiple metabolic toxicities resulting in the production of reactive oxygen species. The redox...

  • Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Kei Arimatsu; Hitomi Yamada; Haruna Miyazawa; Takayoshi Minagawa; Mayuka Nakajima; Ryder, Mark I.; Kazuyoshi Gotoh; Daisuke Motooka; Shota Nakamura; Tetsuya Iida; Kazuhisa Yamazaki // Scientific Reports;5/9/2014, p1 

    Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. Although bacteremias from dental plaque and/or elevated circulating inflammatory cytokines emanating from the inflamed...

  • Emerging Trends in Medication Therapy for Metabolic Syndrome.  // Pharmacy Today;Apr2005, Vol. 11 Issue 4, Special Section p2 

    The article throws light on emerging trends in medication therapy for metabolic syndrome. Metabolic syndrome is a constellation of derangements that generally includes Type 2 diabetes or pre-diabetes. The syndrome is characterized by insulin resistance and the end products are atherosclerosis...

  • Screening of Crude Plant Extracts with Anti-Obesity Activity. Changhyun Roh; Uhee Jung // International Journal of Molecular Sciences;Feb2012, Vol. 13 Issue 2, p1710 

    Obesity is a global health problem. It is also known to be a risk factor for the development of metabolic disorders, type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis. In this study, we screened crude extracts from 400 plants to test their...

  • TGR5 as a Therapeutic Target for Treating Obesity. Min Zhong // Current Topics in Medicinal Chemistry;Mar2010, Vol. 10 Issue 4, p386 

    TGR5 (also known as GPBAR1, M-BAR, BG37, hGPCR19, and AXOR 109) is a specific membrane G-protein-coupled receptor (GPCR) of bile acids (BAs). It has recently become an attractive therapeutic target for the prevention and/or the treatment of obesity and its highly associated Type II diabetes and...

  • The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease. Cani, Patrice D.; Delzenne, Nathalie M. // Current Pharmaceutical Design;5/1/2009, Vol. 15 Issue 13, p1546 

    Obesity is now classically characterized by a cluster of several metabolic disorders, and by a low grade inflammation. The evidence that the gut microbiota composition can be different between healthy and or obese and type 2 diabetic patients has led to the study of this environmental factor as...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics