Challenges in Mucosal HIV Vaccine Development: Lessons from Non-Human Primate Models

Tuero, Iskra; Robert-Guroff, Marjorie
August 2014
Viruses (1999-4915);Aug2014, Vol. 6 Issue 8, p3129
Academic Journal
An efficacious HIV vaccine is urgently needed to curb the AIDS pandemic. The modest protection elicited in the phase III clinical vaccine trial in Thailand provided hope that this goal might be achieved. However, new approaches are necessary for further advances. As HIV is transmitted primarily across mucosal surfaces, development of immunity at these sites is critical, but few clinical vaccine trials have targeted these sites or assessed vaccine-elicited mucosal immune responses. Pre-clinical studies in non-human primate models have facilitated progress in mucosal vaccine development by evaluating candidate vaccine approaches, developing methodologies for collecting and assessing mucosal samples, and providing clues to immune correlates of protective immunity for further investigation. In this review we have focused on non-human primate studies which have provided important information for future design of vaccine strategies, targeting of mucosal inductive sites, and assessment of mucosal immunity. Knowledge gained in these studies will inform mucosal vaccine design and evaluation in human clinical trials.


Related Articles

  • An HIV Vaccine - Evolving Concepts. Johnston, Margaret I.; Fauci, Anthony S. // New England Journal of Medicine;5/17/2007, Vol. 356 Issue 20, p2073 

    The article examines the development of a vaccine for protection against the human immunodeficiency virus (HIV). According to the author, a vaccine that induces strong T-cell mediated immune responses in the absence of broadly neutralizing antibodies may prove beneficial even if the HIV...

  • Application of Outer Membrane Vesicle of Neisseria meningitidis Serogroup B as a New Adjuvant to Induce Strongly Th1-Oriented Responses Against HIV-1. Aghasadeghi, Mohammad Reza; Salmani, Ali Sharifat; Sadat, Seyed Mehdi; Javadi, Foozieh; Memarnejadian, Arash; Vahabpour, Rouhoullah; Zabihollahi, Rezvan; Moshiri, Arfa; Siadat, Seyed Davar // Current HIV Research;Dec2011, Vol. 9 Issue 8, p630 

    Despite the worldwide efforts made in the field of HIV vaccine development, an efficient AIDS vaccine strategy is still vague. Virus-like particles (VLPs) are one of the introduced aspects for HIV vaccine development since the non-replicative nature of HIV VLPs, resulting from the lack of viral...

  • Pre-Existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans. Pine, Samuel O.; Kublin, James G.; Hammer, Scott M.; Borgerding, Joleen; Yunda Huang; Casimiro, Danilo R.; McElrath, M. Juliana // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    The results of the recent Step Study highlight a need to clarify the effects of pre-existing natural immunity to a vaccine vector on vaccine-induced T-cell responses. To investigate this interaction, we examined the relationship between preexisting Ad5 immunity and T-cell cytokine response...

  • Prevalence of HIV and Disease Outcomes on the Medical and Surgical Wards at Kamuzu Central Hospital, Lilongwe, Malawi. Kendig, Claire E.; McCulloch, Denise J.; Rosenberg, Nora E.; Samuel, Jonathan C.; Mabedi, Charles; Shores, Carol G.; Hosseinipour, Mina C.; Matoga, Mitch; Charles, Anthony G. // Tropical Medicine & Health;2013, Vol. 41 Issue 4, p163 

    Introduction: (WHO) recommends HIV Counseling and Testing (HCT) in a range of clinical settings. We describe the characteristics of patients diagnosed with HIV on the medical and surgical wards at a tertiary care hospital in Malawi. Methods: Under the universal opt-out HCT protocol we...

  • AIDS Vaccine A 20-Year Effort. Gard, Carolyn // Current Health 2;Dec2001, Vol. 28 Issue 4, p18 

    Reports the effort of researchers for finding AIDS vaccine in the United States. Definition of AIDS; Description of HIV; Destruction of T cells in the body by HIV.

  • Immune activation alters cellular and humoral responses to yellow fever 17D vaccine. Muyanja, Enoch; Ssemaganda, Aloysius; Ngauv, Pearline; Cubas, Rafael; Perrin, Helene; Srinivasan, Divya; Canderan, Glenda; Lawson, Benton; Kopycinski, Jakub; Graham, Amanda S.; Rowe, Dawne K.; Smith, Michaela J.; Isern, Sharon; Michael, Scott; Silvestri, Guido; Vanderford, Thomas H.; Castro, Erika; Pantaleo, Giuseppe; Singer, Joel; Gillmour, Jill // Journal of Clinical Investigation;Jul2014, Vol. 124 Issue 7, p3147 

    Background. Defining the parameters that modulate vaccine responses in African populations will be imperative to design effective vaccines for protection against HIV, malaria, tuberculosis, and dengue virus infections. This study aimed to evaluate the contribution of the patient-specific immune...

  • U-turn on HIV vaccine.  // New Scientist;8/2/2008, Vol. 199 Issue 2667, p7 

    The article reports on the cancellation to test the new generation of HIV vaccine on more than 8,500 people in the U.S. The cause of the cancellation to test the vaccine, which is designed to prime an immune response to HIV-infected cells, is the string of failed clinical trials. Moreover, a...

  • Gastric Bypass Surgery Is Followed by Lowered Blood Pressure and Increased Diuresis -- Long Term Results from the Swedish Obese Subjects (SOS) Study. Hallersund, Peter; Sjöström, Lars; Olbers, Torsten; Lönroth, Hans; Jacobson, Peter; Wallenius, Ville; Näslund, Ingmar; Carlsson, Lena M.; Fändriks, Lars // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    Objective: To compare two bariatric surgical principles with regard to effects on blood pressure and salt intake. Background: In most patients bariatric surgery induces a sustained weight loss and a reduced cardiovascular risk profile but the long-term effect on blood pressure is uncertain....

  • New trial of HIV vaccine in gay men begins. Bajko, Matthew S. // Bay Area Reporter;10/1/2009, Vol. 39 Issue 40, p1 

    The article reports that researchers are recruiting gay men for participation in the HVTN 505 Study, which aims to find a vaccine for HIV.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics