TITLE

Evolutionary, Structural and Biochemical Evidence for a New Interaction Site of the Leptin Obesity Protein

AUTHOR(S)
Gaucher, Eric A.; Miyamoto, Michael M.; Benner, Steven A.
PUB. DATE
April 2003
SOURCE
Genetics;Apr2003, Vol. 163 Issue 4, p1549
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.
ACCESSION #
9683464

 

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