TITLE

Diagnosis, Prognosis and Therapeutic Role of Circulating miRNAs in Cardiovascular Diseases

AUTHOR(S)
Sayed, Ali Sheikh Md; Xia, Ke; Salma, Umme; Yang, Tianlun; Peng, Jun
PUB. DATE
June 2014
SOURCE
Heart, Lung & Circulation;Jun2014, Vol. 23 Issue 6, p503
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although much progress has been made for cardiovascular diseases in diagnosis, treatment and prognosis during the past two decades, the clinical need for a novel diagnostic biomarker and new therapeutic interventions to decrease the cardiovascular disease incidence is ongoing. MicroRNAs (miRNAs) are endogenous, small (∼22 nucleotides), single-stranded, non-coding RNAs that regulate gene expression and are detectable in whole blood, serum, plasma, urine and other body fluids in a highly stable form. Accumulating evidence suggests that miRNAs are potential novel biomarkers with high sensitivity for early diagnosis and modern treatment for cardiovascular diseases. Altered circulating miRNAs expressions have been reported in acute myocardial infarction (AMI), acute coronary syndrome (ACS), stable coronary artery disease, heart failure, atherosclerosis, essential hypertension and stroke. In the present review, we examine more recent data regarding circulating miRNAs and their potential roles in diagnosis, prognosis and therapeutic strategies for cardiovascular diseases. In addition, we briefly present our own recent experience in detecting circulating miRNAs, and the significance of these miRNAs in AMI prognosis.
ACCESSION #
96344038

 

Related Articles

  • Clinical Assessment of Cardiovascular Disorders by Cardiac Biomarkers. Gupta, Akansha; Shukla, Prabhat; Ashwlayan, Vrish Dhwaj // International Journal of Pharmaceutical Sciences Review & Resear;Nov/Dec2014, Vol. 29 Issue 1, p87 

    Cardiovascular diseases (CVD) are the primary cause of morbidity and mortality in the country. Therefore, Blood cardiac biomarkers (CB) have become progressively more accurate for estimating cardiac abnormalities for the last 40 years. Biomarkers are a significant tool to better identify...

  • Looking at the Crystal Ball. Rizzo, Toni; Brugada, Josep; Vrints, Christian J. M.; Cribier, Alain; Fuster, Valentin // MD Conference Express;Oct2015, Vol. 15 Issue 28, p9 

    Reductions in cardiovascular mortality have been achieved via improved prevention, diagnosis, and treatment. However, costs have risen accordingly. A future emphasis on health promotion and disease prevention through research, education, and mitigation of disease-causing environmental factors...

  • Machine Learning Approach to Extract Diagnostic and Prognostic Thresholds: Application in Prognosis of Cardiovascular Mortality. Mena, Luis J.; Orozco, Eber E.; Felix, Vanessa G.; Ostos, Rodolfo; Melgarejo, Jesus; Maestre, Gladys E. // Computational & Mathematical Methods in Medicine;Jan2012, p1 

    Machine learning has become a powerful tool for analysing medical domains, assessing the importance of clinical parameters, and extracting medical knowledge for outcomes research. In this paper, we present a machine learning method for extracting diagnostic and prognostic thresholds, based on a...

  • MicroRNAs and human diseases: diagnostic and therapeutic potential. Maqbool, Raihana; Hussain, Mahboob // Cell & Tissue Research;Oct2014, Vol. 358 Issue 1, p1 

    MicroRNAs (miRNAs) are endogenous, non-coding small RNAs that regulate gene expression at the post-transcriptional level. Recent studies have shown that miRNAs are aberrantly expressed in various human diseases, ranging from cancer to cardiovascular hypertrophy. The expression profiles of the...

  • Training in nuclear cardiology: What's new? Hage, Fadi; Hage, Fadi G // Journal of Nuclear Cardiology;Oct2015, Vol. 22 Issue 5, p861 

    No abstract available.

  • MicroRNAs in cardiovascular disease: an introduction for clinicians. Romaine, Simon P. R.; Tomaszewski, Maciej; Condorelli, Gianluigi; Samani, Nilesh J. // Heart;Jun2015, Vol. 101 Issue 12, p921 

    MicroRNAs (miRNAs) are small, non-coding, RNA molecules approximately 22 nucleotides in length which act as post-transcriptional regulators of gene expression. Individual miRNAs have been shown to regulate the expression of multiple genes. Conversely, the expression of individual genes can be...

  • Osteoprotegerin in Cardiometabolic Disorders. Pérez de Ciriza, C.; Lawrie, A.; Varo, N. // International Journal of Endocrinology;5/11/2015, Vol. 2015, p1 

    Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for...

  • An electronic medical record-linked biorepository to identify novel biomarkers for atherosclerotic cardiovascular disease. Zi Ye; Kalloo, Fara S.; Dalenberg, Angela K.; Kullo, Iftikhar J. // Global Cardiology Science & Practice;2013, Vol. 2013 Issue 2, p1 

    Background: Atherosclerotic vascular disease (AVD), a leading cause of morbidity and mortality, is increasing in prevalence in the developing world. We describe an approach to establish a biorepository linked to medical records with the eventual goal of facilitating discovery of biomarkers for...

  • A 61-year-old man with hyperpigmentation. Lindman, Brian R.; Breyley, Jared G.; Schilling, Joel D.; Vatterott, Anna M.; Zajarias, Alan; Maniar, Hersh S.; Damiano Jr, Ralph J.; Moon, Marc R.; Lawton, Jennifer S.; Gage, Brian F.; Sintek, Marc A.; Aquino, Alejandro; Holley, Christopher L.; Patel, Neil M.; Lawler, Cassandra; Lasala, John M.; Novak, Eric // Heart;Sep2015, Vol. 101 Issue 17, p1412 

    Objective: In heart failure populations without aortic stenosis (AS), the prognostic utility of multiple biomarkers in addition to clinical factors has been demonstrated. We aimed to determine whether multiple biomarkers of cardiovascular stress are associated with mortality in patients with AS...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics