TITLE

Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain

AUTHOR(S)
Puelles, Eduardo; Acampora, Dario; Lacroix, Emmanuel; Signore, Massimo; Annino, Alessandro; Tuorto, Francesca; Filosa, Stefania; Corte, Giorgio; Wurst, Wolfgang; Ang, Siew-Lan; Simeone, Antonio
PUB. DATE
May 2003
SOURCE
Nature Neuroscience;May2003, Vol. 6 Issue 5, p453
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Organizing centers emit signaling molecules that specify different neuronal cell types at precise positions along the anterior-posterior (A-P) and dorsal-ventral (D-V) axes of neural tube during development. Here we report that reduction in Otx proteins near the alar-basal plate boundary (ABB) of murine midbrain resulted in a dorsal shift of Shh expression, and reduction in Otx proteins at the midbrain-hindbrain boundary (MHB) resulted in an anterior expansion of the Fgf8 domain. Our data thus indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression. Furthermore, this control is effective for conferring proper cell identity in the floor-plate region of midbrain and does not require an Otx2-spedfic property. We propose that this mechanism may provide both A-P and D-V positional information to neuronal precursors located within the midbrain.
ACCESSION #
9597794

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics