TITLE

Early Impact of Bariatric Surgery on Type II Diabetes, Hypertension, and Hyperlipidemia: A Systematic Review, Meta-Analysis and Meta-Regression on 6,587 Patients

AUTHOR(S)
Ricci, Cristian; Gaeta, Maddalena; Rausa, Emanuele; Macchitella, Yuri; Bonavina, Luigi
PUB. DATE
April 2014
SOURCE
Obesity Surgery;Apr2014, Vol. 24 Issue 4, p522
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: This study aims to evaluate the 12-24-month impact of bariatric surgery on the foremost modifiable traditional risk factors of cardiovascular disease. Methods: A systematic review and meta-analysis of prospective interventional studies reporting the most commonly performed laparoscopic surgical procedures, i.e., Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB), and cardiovascular risk reduction after surgery. Results: The bibliographic research conducted independently by two authors yielded 18 records. When looking at RYGB and AGB separately, we observed a relevant heterogeneity ( I index ≥87 %) when BMI reduction was considered as the main outcome. When hypertension, type II diabetes, and hyperlipidemia risk reduction was estimated, a highly significant beneficial effect was found. The risk reduction was 0.33 [0.26; 0.42] for type II diabetes, 0.52 [0.42; 0.64] for hypertension, and 0.39[0.27; 0.56] for hyperlipidemia ( P < 0.0001 for all outcomes considered). When looking at surgical technique separately, a higher but not statistically significant risk reduction for all outcomes considered was found. Results from the meta-regression approach showed an inverse relation between cardiovascular risks and BMI reduction. Conclusions: The present study showed an overall reduction of cardiovascular risk after bariatric surgery. According to our analysis a BMI reduction of 5 after surgery corresponds to a type II diabetes reduction of 33 % (as reported by Peluso and Vanek (Nutr Clin Pract 22(1):22-28, ); SAS Institute Inc., (-2004)), a hypertension reduction of 27 % (as reported by Buchwald and Oien (Obes Surg 23(4):427-436, ); Valera-Mora et al. (Am J Clin Nutr 81(6):1292-1297, )), and a hyperlipidemia reduction of 20 %(as reported by Adams et al. (JAMA 308(11):1122-31, )); Alexandrides et al. (Obes Surg 17(2):176-184, ). In summary, our study showed that laparoscopic bariatric surgery is an effective therapeutic option to reduce the cardiovascular risk in severe obese patients.
ACCESSION #
95298599

 

Related Articles

  • A meta-analysis of the medium- and long-term effects of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass. Gu, Lihu; Huang, Xiaojing; Li, Shengnan; Mao, Danyi; Shen, Zefeng; Khadaroo, Parikshit Asutosh; Ng, Derry Minyao; Chen, Ping // BMC Surgery;2/12/2020, Vol. 20 Issue 1, p1 

    Background: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are two representative bariatric surgeries. This study aimed to compare the effects of the LSG and LRYGB based on high-quality analysis and massive amount of data.Methods:...

  • Therapeutic Inertia: Still a Long Way to Go That Cannot Be Postponed. Mata-Cases, Manel; Franch-Nadal, Josep; Gratacòs, Mònica; Mauricio, Dídac // Diabetes Spectrum;Feb2020, Vol. 33 Issue 1, p50 

    In the context of type 2 diabetes, the definition of therapeutic inertia should include the failure not only to intensify therapy, but also to deintensify treatment when appropriate and should be distinguished from appropriate inaction in cases justified by particular circumstances. Therapy...

  • Diabetes and chronic kidney disease: a ticking time bomb. Killeen, Siobhan // Journal of Renal Nursing;2012, Vol. 4 Issue 5, p222 

    Chronic kidney disease (CKD) is one of the long-term complications associated with diabetes and is an independent risk factor for cardiovascular disease, which is why it was added to the Quality and Outcomes Framework (QOF) in 2006. In this article, Ruth Killeen identifies the cardiovascular...

  • Bariatric Surgery for Type 2 Diabetes Reversal: The Risks. KEIDAR, ANDREI // Diabetes Care;May2011 Supplement 2, Vol. 34, pS361 

    The article focuses on the risks associated with bariatric surgery done on people with type 2 diabetes. According to the findings of the Nurses' Health Study, it was revealed that there is a direct relationship between increasing body mass index (BMI) and relative risk of premature death. The...

  • Diabetes en México. Estudio CARMELA. Peña, Jorge Escobedo-de la; Buitrón-Granados, Luisa Virginia; Ramírez-Martínez, Jesús Cenobio; Chavira-Mejía, Raymundo; Schargrodsky, Herman; Champagne, Beatriz Marcet // Cirugia y Cirujanos;sep/oct2011, Vol. 79 Issue 5, p424 

    Background: Diabetes has demonstrated an epidemic behavior in Mexico, which is among the top countries with the highest number of patients with diabetes. The objective of this study was to estimate the prevalence of type 2 diabetes in Mexico City and its relation with some cardiovascular risk...

  • Impactul diabetului zaharat asupra funcÈ›iei diastolice la pacienÈ›ii hipertensivi. DIACONU, CAMELIA // Romanian Journal of Medical Practice;2010, Vol. 5 Issue 2, p97 

    Introduction: Type 2 diabetes mellitus is a well-known cardiovascular risk factor. Diastolic dysfunction is considered a precursor of cardiac failure and can be diagnosed by echocardiography, being common in patients with type 2 diabetes mellitus without clinical manifestations of cardiac...

  • Lipid profile in type 2 diabetic and hypertensive population in Western Algeria. Gormat, N. Brixi; Benmansour, F.; Hammas, A. // Annals of Biological Research;2011, Vol. 2 Issue 4, p447 

    Dyslipidemia in diabetics are as high blood pressure to take very seriously, given the significant increase in cardiovascular risks they pose to patients. Anomalies of lipoprotein metabolism are of major importance because of the risks atherogenic increased in diabetic patients. [4, 11] In this...

  • A cross-sectional study of type -2 diabetic females at a higher CVD risk owing to a strong correlation of Systolic hypertension to CVD risk factors. purohit, Purvi // International Journal of Biological & Medical Research;May2012, Vol. 3 Issue 3, p1905 

    Aim - We aimed at evaluating the CVD risk in the female type 2 diabetic patients as compared to the type - 2 diabetic males at diagnosis. Background - India faces dual epidemic of diabetes and CVDs. Hypertension affects approximately 70% of patients with diabetes and is approximately twice as...

  • PON 1 ACTIVITY IN NEWLY DETECTED TYPE 2 DIABETES MELLITUS PATIENTS WITH & WITHOUT HYPERTENSION. BELWALKAR, G. J.; JAGTAP, P. E.; NAGANE, N. S.; DHONDE, S. // International Journal of Pharma & Bio Sciences;Oct-Dec2013, Vol. 4 Issue 4, pB-1298 

    The prevalence of diabetes mellitus & hypertension has been increasing worldwide. Diabetes mellitus is an independent risk factor for coronary artery disease & risk is markedly increased when hypertension is present. Paraoxonase (PON1) is an HDL - associated esterase / lactonase & its activity...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics