Evaluation of Safety and Anti-obese Activity of a Polyherbal Formulation -- Simlim Capsule

Shah, Bijal N.; Soni, Hardik K.; Patel, Ghanshyam R.; Patel, Pooja D.; Paranjape, Archana N.
May 2013
International Journal of Pharmaceutical & Phytopharmacological R;
Obesity is one the most common and now considered as global health problem which triggers many other metabolic disorders. In the present study, a polyherbal formulation - Simlim Capsule was evaluated for its anti-obesity activity in high fat diet (HFD) induced male Wistar albino rats. It was also compared with modern medicine available in the market i.e. Orlistat. It was revealed that HFD elicited significant increase in body weight, daily food intake, and serum levels of glucose, total cholesterol, LDL Cholesterol, VLDL cholesterol, Triglycerides, ALT and AST level. Treatment with Simlim Capsule in dose of 180mg/kg (p.o) inhibited rise in body weight and daily food intake which shows its hypophagic activity. It also reduced lipid level such as triglyceride, LDL, VLDL and serum glucose levels while high density lipoproteins (HDL) was found increased which indicates its cardio protective activity. It has also significantly reduced ALT and AST level in serum. Histopathological changes of liver like hepatic steatosis induced by high fat diet was overcame by Simlim capsule and results were found comparable with Orlistat. Hence, it was concluded that Simlim Capsule is having anti-obesity activity by reducing cholesterol and triglyceride content, thus helping to reduce weight.


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