Synthesis of several new lanthanide Glimepiride complexes for evaluation of microbial activity

Abd El-Wahed, M.; El-Megharbel, Samy; El-Sayed, Mohamed; Zahran, Yasmin; Refat, Moamen
December 2013
Russian Journal of General Chemistry;Dec2013, Vol. 83 Issue 12, p2438
Academic Journal
The complexation between lanthanide metal ions like Nd(III), Tb(III), and Er(III) with Glimepiride produces 1: 1 molar ratio (metal: Glimepiride) monodentate complexes of general formula: [M(GMP)(HO)]Cl· xHO, where: M = Nd, Tb, and Er, x = 1, 10, respectively. The structures of obtained compounds were assigned by IR, H NMR and UV/Vis spectra. Themogravimetric analysis and kinetic thermodynamic parameters have proved the thermal stability of Glimepiride complexes. Obtained lanthanide complexes showed significant effect against some bacteria and fungi.


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