Application of Hydrotropic Solubilisation in Simultaneous Estimation of Atenolol and Amlodipine Besylate

Gurumurthy, V.; Deveswaran, R.; Bharath, S.; Basavaraj, B.V.; Madhavan, V.
January 2012
Asian Journal of Research in Chemistry;Jan2012, Vol. 5 Issue 1, p57
Academic Journal
The present investigation was aimed to estimate atenolol and amlodipine besylate simultaneously from bulk drug and tablets using hydrotropic solubilization technique employing 4M urea as hydrotropic solvent. Atenolol showed maximum absorbance at 224.5nm, whereas amlodipine besylate showed maximum absorbance at 237nm. The solubility of both atenolol and amlodipine besylate was increased to greater extent in 4M urea. Both the drugs showed linearity in the concentration range of 4-20μg/ml. The analysis of tablets indicated good correlation between the estimated and label claim. The values of LOD and LOQ were low, which confirmed the good sensitivity of the proposed method. The results of recovery studies showed that any small changes in drug concentration can be determined accurately by the proposed method. The method adopted is new, simple, accurate and cost-effective in the simultaneous estimation of atenolol and amlodipine besylate using hydrotropic solubilization phenomenon. This method can be successfully employed for routine analysis of atenolol and amlodipine besylate tablets.


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