Effects of sleeve gastrectomy on parameters of lipid and glucose metabolism in obese women -- 6 months after operation

Bužga, Marek; Holéczy, Pavol; Švagera, Zdeněk; Švorc Jr, Pavol; Zavadilová, Vladislava
January 2013
Videosurgery & Other Miniinvasive Techniques / Wideochirurgia i;2013, Vol. 2013 Issue 1, p22
Academic Journal
Introduction: Surgical intervention in obesity is today the most effective treatment method in high level obesity management with long-term clinical results and satisfaction of operated patients. Bariatric interventions not only ensure body weight reduction, but may influence lipid and saccharide metabolism as well. Aim: To monitor the dynamics of changes in selected lipid and glucose metabolism parameters after laparoscopic sleeve gastrectomy (LSG) in obese women. Material and methods: During the period from September 2010 to June 2011, 35 women, operated on by sleeve gastrectomy, were monitored within a pilot open study. Parameters of lipid and glucose metabolism were measured, and body composition was evaluated, using dual X-ray absorptiometry (DXA). Laboratory parameters were assessed prior to LSG and at 3 and 6 months after the surgery. Results: Data of the 35 study subjects are presented. Average age was 41.9 years (27-68 years). Six months after LSG, body weight reduction was achieved from 117.7 ±17.1 kg to 91.2 ±17.2 kg (p < 0.001). The body mass index (BMI) dropped from 42.7 ±4.7 kg/m2 to 33.0 ±4.9 kg/m2 (p < 0.001). The excess weight loss (EWL) was 49.01%. High density lipoprotein (HDL) cholesterol increased from 1.29 mmol/l to 1.39 mmol/l (p < 0.025). Triacylglycerols dropped from 1.97 mmol/l to 1.31 mmol/l (p < 0.001). Glycated hemoglobin dropped from 4.03% to 3.59% (p < 0.001), and C-peptide decreased from 1703 pmol/l to 1209 pmol/l (p < 0.002). The observed changes of low density lipoprotein (LDL) cholesterol, total cholesterol or fasting glucose levels were not significant. Six months after LSG, both weight and BMI significantly decreased. Conclusions: Six months after the operation, glucose homeostasis was improved. Despite the rather short-term monitoring period, our study did confirm LSG to influence not only total weight loss and fat tissue reduction but to improve risk factors, mainly glucose homeostasis and dyslipidemia, as well.


Related Articles

  • State of the Art: Sleeve Gastrectomy. Wölnerhanssen, Bettina; Peterli, Ralph // Digestive Surgery;May2014, Vol. 31 Issue 1, p40 

    In the biliopancreatic diversion (BPD) type duodenal switch, sleeve gastrectomy was applied as the restrictive part instead of a horizontal gastrectomy in the original Scopinaro type BPD. Laparoscopic sleeve gastrectomy (LSG) was used as a first step in a staged concept for high-risk patients...

  • Magenstrasse and Mill Gastroplasty and Sleeve Gastrectomy as Treatment for Morbid Obesity. ARROYO, KERVIN; ALKHOURY, FUAD; NADZAM, GEOFFREY; VALIN, ELMER // Connecticut Medicine;Nov2010, Vol. 74 Issue 10, p589 

    Background: Laparoscopic nonbanded restrictive procedures are becoming more popular as staging and primary operations in bariatric surgery. The Magenstrasse and Mill (MM) procedure produces a restrictive gastric tubular pouch based along the lesser curvature; for the most part anatomy and...

  • Early Postoperative Changes of HDL Subfraction Profile and HDL-Associated Enzymes After Laparoscopic Sleeve Gastrectomy. Doğan, Serdar; Aslan, Ibrahim; Eryılmaz, Ramazan; Ensari, Cemal Ozben; Bilecik, Tuna; Aslan, Mutay // Obesity Surgery;Dec2013, Vol. 23 Issue 12, p1973 

    This study aimed to determine early postoperative changes of LDL/HDL subfraction profile and HDL-associated enzymes following laparoscopic sleeve gastrectomy (LSG). Thirteen obese patients (mean body mass index (BMI) 52.74 ± 10.97 kg/m 2) underwent LSG and normal weight...

  • EVEN HEFTY GUYSGETALIFT FROM WEIGHTS. BARROSO, MARK // Men's Fitness;Jan/Feb2014, Vol. 30 Issue 1, p16 

    The article reports on a study by Christian Roberts and colleagues that was published in the "Journal of Applied Physiology," which found that strength fitness appeared to be more important to high density lipoproteins (HDL) function than body mass index (BMI).

  • Lipid Profile Changes in the Severely Obese after Laparoscopic Sleeve Gastrectomy (LSG), 1, 3, and 5 Years after Surgery. Strain, Gladys; Saif, Taha; Ebel, Faith; Dakin, Gregory; Gagner, Michel; Costa, Ricardo; Chiu, Ya-Lin; Pomp, Alfons // Obesity Surgery;Feb2015, Vol. 25 Issue 2, p285 

    Background: Since there is an increasing acceptance of the laparoscopic sleeve gastrectomy (LSG) and limited information regarding its effect on cardiac risk factors, we assessed lipid profiles. Methods: A retrospective review of patient records pre and post LSG was performed. Analysis of...

  • Perfil lipídico e obesidade em homens de um município daRegião Sul do Brasil. Borba, Ericksen; Philipi, Ariella; Nascimento, Filipe; Guimarães, Alexandre; Boff, Roberta; Sada, Patrícia; Funchal, Cláudia; Dani, Caroline // Scientia Medica;Mar2012, Vol. 22 Issue 1, p18 

    Aims: To evaluate the lipid profile and its relationship with obesity in men from Flores da Cunha, Rio Grande do Sul. Methods: A population-based cross-sectional study included men living in the county of Flores da Cunha, located in northeastern Rio Grande do Sul, the southernmost state in...

  • Association of Two CETP Polymorphisms With HDL Levels in the Chinese Obese Population. Xiaoyang Ruan; Lina Ma; Shuyu Wang; Klaus Lindpaintner; Xiangjun Liu; Binbin Wang; Zuoqi Peng; Xu Ma; Maosheng Cheng; Jinghai Zhang; Lisheng Liu; Xingyu Wang // Obesity (19307381);Dec2009, Vol. 17 Issue 12, p2196 

    The association of two cholesterol ester transfer protein (CETP) polymorphisms, D442G and TAQIB (B1→B2), with high-density lipoprotein (HDL) levels in 932 Chinese obese individuals (BMI ≥ 27) was investigated in comparison with normal controls (BMI ≤ 24). Independent...

  • Clinical: Journals Watch - Pregnancy care and depression.  // GP: General Practitioner;9/25/2009, p26 

    The article offers information on the research related to the rate of gestational diabetes and metabolic syndrome in the women who take, iron supplementation during pregnancy in Great Britain. It mentions that taking iron supplement reduces high density lipoproteins (HDL) level, increase...

  • Inequalities in bariatric surgery in Australia: findings from 49 364 obese participants in a prospective cohort study. Korda, Rosemary J.; Joshy, Grace; Jorm, Louisa R.; Butler, James R. G.; Banks, Emily // Medical Journal of Australia;12/3/2012, Vol. 197 Issue 11/12, p631 

    The article presents a study to investigate variation and to quantify socioeconomic inequalities in the uptake of primary bariatric surgery in an obese population in Australia. The prospective population-based cohort study involved 49,364 individuals aged 45-74 years with body mass index (BMI)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics