Screening for chromosomal abnormalities by maternal age and fetal nuchal translucency thickness: The Jordanian experience

Amarin, Vera N.; Alsaied, Hussein M.; Dmour, Hussein h.; Al Quran, Fatmeh
January 2013
Middle East Journal of Internal Medicine;Jan2013, Vol. 6 Issue 1, p20
Academic Journal
Objective: To screen for chromosomal defects on the basis of maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation. Method: Fetal nuchal translucency thickness was measured by ultrasound examination at 10-14 weeks of gestation in living singleton pregnancies in women attending routine antenatal care at Prince Ali Bin Hussein. Amman Jordan. The risks for trisomy 21 and other chromosomal defects by ultrasound measurment of fetal nuchal translucency thickness and maternal age were calculated, using the software provided by The Fetal Medicine Foundation. Results: Chromosomal defects were diagnosed in 10 cases, including 4 cases of trisomy 21 and 6 cases with other chromosomal abnormalities (trisomy 18, 13, triploidy, Turner). The estimated risk based on maternal age and fetal NT was 1 in 300 .Conclusion: The combination of maternal age and fetal nuchal translucency thickness was an effective method of screening for chromosomal defects.


Related Articles

  • Undergoing prenatal screening for Down's syndrome: presentation of choice and information in Europe and Asia. Hall, Sue; Chitty, Lyn; Dormandy, Elizabeth; Hollywood, Amelia; Wildschut, Hajo I. J.; Fortuny, Albert; Masturzo, Bianca; Šantavý, Jiøí; Kabra, Madhulika; Ma, Runmei; Marteau, Theresa M. // European Journal of Human Genetics;May2007, Vol. 15 Issue 5, p563 

    To date, studies assessing whether the information given to people about screening tests facilitates informed choices have focussed mainly on the UK, US and Australia. The extent to which written information given in other countries facilitates informed choices is not known. The aim of this...

  • Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening. Loane, Maria; Morris, Joan K; Addor, Marie-Claude; Arriola, Larraitz; Budd, Judith; Doray, Berenice; Garne, Ester; Gatt, Miriam; Haeusler, Martin; Khoshnood, Babak; Klungsøyr Melve, Kari; Latos-Bielenska, Anna; McDonnell, Bob; Mullaney, Carmel; O'Mahony, Mary; Queißer-Wahrendorf, Annette; Rankin, Judith; Rissmann, Anke; Rounding, Catherine; Salvador, Joaquin // European Journal of Human Genetics;Jan2013, Vol. 21 Issue 1, p27 

    This study examines trends and geographical differences in total and live birth prevalence of trisomies 21, 18 and 13 with regard to increasing maternal age and prenatal diagnosis in Europe. Twenty-one population-based EUROCAT registries covering 6.1 million births between 1990 and 2009...

  • Diagnostic test for Down's added to hospital.  // Hudson Valley Business Journal;6/13/2005, Vol. 16 Issue 12, p22 

    The article informs that a new-diagnostic test is being offered at Pascack Valley Hospital for all pregnant women to estimate the risk of their babies having Down's syndrome. The new test, called a Nuchal Translucency Exam, is a non-invasive ultrasound that can be performed on all women,...

  • Nuchal translucency assessment: What else can it tell us? Copel, Joshua A.; Timor-Tritsch, Ilan E. // Contemporary OB/GYN;Nov2006, Vol. 51 Issue 11, p75 

    The article discusses a variety of issues concerning nuchal translucency (NT) assessment. NT assessment has been famous because of its ability to detect risk for fetal Down syndrome. A study found that increased NT with is also associated with congenital heart disease. Details of the BUN and...

  • Prenatal Diagnosis of Chromosome Abnormalities: A 13-Year Institution Experience. Comas, Carmen; Echevarria, Mónica; Rodríguez, María Ángeles; Rodríguez, Ignacio; Serra, Bernat; Cirigliano, Vincenzo // Diagnostics (2075-4418);Dec2012, Vol. 2 Issue 4, p57 

    Objective: To analyze trends in screening and invasive prenatal diagnosis of chromosome abnormalities (CA) over a 13-year period and correlate them to changes in the national prenatal screening policy. Methods: We retrospectively reviewed Down syndrome (DS) screening tests and fetal karyotypes...

  • Quadruple test heightens prenatal detection of Down syndrome.  // Contemporary OB/GYN;Jun2003, Vol. 48 Issue 6, p16 

    Presents two studies on prenatal screening for Down's syndrome using the quadruple test. Detection rate for the quadruple test; Sensitivity of the quadruple test; Benefits of the quadruple test.

  • Sex chromosome trisomies in Europe: prevalence, prenatal detection and outcome of pregnancy. Boyd, Patricia Anne; Loane, Maria; Garne, Ester; Khoshnood, Babak; Dolk, Helen // European Journal of Human Genetics;Feb2011, Vol. 19 Issue 2, p231 

    This study aims to assess prevalence and pregnancy outcome for sex chromosome trisomies (SCTs) diagnosed prenatally or in the first year of life. Data held by the European Surveillance of Congenital Anomalies (EUROCAT) database on SCT cases delivered 2000-2005 from 19 population-based registries...

  • Maternal Age and Down's Syndrome. Shiono, Hiroshi; Kadowaki, Junichi; Nakao, Tooru // Clinical Pediatrics;Mar1975, Vol. 14 Issue 3, p241 

    The article reports that the incidence of Down's syndrome increases with advancing maternal age. Scientists have showed that the distribution of maternal age in Down's syndrome is bimodal, with one peak at about the maternal age of 27 and another at age 37. Recently, scientists have noted that...

  • The proportions of Down's syndrome pregnancies detected prenatally in England and Wales from 1989 to 2004. Morris, J. K.; Alberman, E.; Mutton, D. // Journal of Medical Screening;Dec2006, Vol. 13 Issue 4, p163 

    Objectives: The proportion of Down's syndrome pregnancies detected prenatally in England and Wales is lower in younger mothers than in older mothers. This paper examines the reasons for this apparent age inequality. Methods: We used data from the National Down Syndrome Cytogenetic Register...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics