TITLE

Temporal and spatial coordination of exocytosis and endocytosis

AUTHOR(S)
Gundelfinger, Eckart D.; Kessels, Michael M.; Qualmann, Britta
PUB. DATE
February 2003
SOURCE
Nature Reviews Molecular Cell Biology;Feb2003, Vol. 4 Issue 2, p127
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In secretory cells, exocytosis and compensatory endocytosis are tightly coupled membrane trafficking processes that control the surface area and composition of the plasma membrane. While exocytic and endocytic processes have been studied independently in great detail, at present there is much interest in understanding the mode of their coupling. This review discusses emerging insights into the coupling of these processes, both in the chemical synapses of neurons and in non-neuronal cells.
ACCESSION #
9019692

 

Related Articles

  • Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+. Yamashita, Takayuki; Eguchi, Kohgaku; Saitoh, Naoto; von Gersdorff, Henrique; Takahashi, Tomoyuki // Nature Neuroscience;Jul2010, Vol. 13 Issue 7, p838 

    Ca2+ is thought to be essential for the exocytosis and endocytosis of synaptic vesicles. However, the manner in which Ca2+ coordinates these processes remains unclear, particularly at mature synapses. Using membrane capacitance measurements from calyx of Held nerve terminals in rats, we found...

  • A simulation study on the Ca2+-independent but voltage-dependent exocytosis and endocytosis in dorsal root ganglion neurons. Hua Yang; Chen Zhang; Hui Zheng; Wei Xiong; Zhuan Zhou; Tao Xu; Jiu Ding // European Biophysics Journal;Nov2005, Vol. 34 Issue 8, p1007 

    In patch-clamped somata of dorsal root ganglion (DRG) neurons, two types of secretion have been proposed: Ca2+-dependent secretion and Ca2+-independent but voltage-dependent secretion (CIVDS). The Ca2+-induced and the depolarization-induced membrane capacitance ( C m) increases contribute 80 and...

  • Calcium: the common theme in vesicular cycling. Abenavoli, Alessandra; Montagna, Marcella; Malgaroli, Antonio // Nature Neuroscience;Feb2001, Vol. 4 Issue 2, p117 

    Discusses the maintenance of synaptic structure and function through balance between vesicle fusion with the exocytosis and the endocytosis. Continuous increase in size of synapses through disruption of the endocytosis; Dependency of synaptic vesicle on calcium; Regulation of the endocytosis...

  • Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Pérez-Otaño, Isabel; Luján, Rafael; Tavalin, Steven J.; Plomann, Markus; Modregger, Jan; Xiao-Bo Liu; Jones, Edward G.; Heinemann, Stephen F.; Lo, Donald C.; Ehlers, Michael D. // Nature Neuroscience;May2006, Vol. 9 Issue 5, p611 

    A key step in glutamatergic synapse maturation is the replacement of developmentally expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit composition, electrophysiological properties and propensity to elicit synaptic plasticity. However, the mechanisms...

  • Synaptic vesicles retain their identity through the endocytic cycle. Murthy, Venkatesh N.; Stevens, Charles F. // Nature;4/2/1998, Vol. 392 Issue 6675, p497 

    Presents research which tested the classical model of synaptic-vesicle recycling. Exocytosis and endocytosis related to the vesicular membrane; Unresolved issues regarding endocytosis at central synapses; What the classical model of synaptic-vesicle recycling is; Results contrary to classical...

  • Synaptic vesicle retrieval: still time for a kiss. Kjaerulff, Ole; Verstreken, Patrik; Bellen, Hugo J. // Nature Cell Biology;Nov2002, Vol. 4 Issue 11, pE245 

    After exocytosis, synaptic vesicles are reformed by slow clathrin-mediated endocytosis. However, evidence also supports the existence of faster retreival mechanisms in neurons, including 'kiss-andrun', where vesicles fuse only partially with the presynaptic membrane before being retrieved. New...

  • Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical. Wienisch, Martin; Klingauf, Jurgen // Nature Neuroscience;Aug2006, Vol. 9 Issue 8, p1019 

    Upon exocytosis, synaptic vesicle proteins are released into the plasma membrane and have to be retrieved by compensatory endocytosis. When green fluorescent protein–labeled versions of the vesicle proteins synaptobrevin-2 and synaptotagmin-1 are overexpressed in rat hippocampal neurons,...

  • Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+-sensor proteins. Braunewell, Karl-Heinz; Szanto, Andres // Cell & Tissue Research;Jan2009, Vol. 335 Issue 2, p301 

    The visinin-like protein (VSNL) subfamily, including VILIP-1 (the founder protein), VILIP-2, VILIP-3, hippocalcin, and neurocalcin δ, constitute a highly homologous subfamily of neuronal calcium sensor (NCS) proteins. Comparative studies have shown that VSNLs are expressed predominantly in...

  • T-type channels-secretion coupling: evidence for a fast low-threshold exocytosis. Carbone, E.; Marcantoni, A.; Giancippoli, A.; Guido, D.; Carabelli, V. // Pflugers Archiv European Journal of Physiology;Dec2006, Vol. 453 Issue 3, p373 

    T-type channels are transient low-voltage-activated (LVA) Ca2+ channels that control Ca2+ entry in excitable cells during small depolarizations around resting potential. Studies in the past 20 years focused on the biophysical, physiological, and molecular characterization of T-type channels in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics