TITLE

Association between metabolic syndrome, diabetes mellitus and prostate cancer risk

AUTHOR(S)
Lawrence, Y R; Morag, O; Benderly, M; Boyko, V; Novikov, I; Dicker, A P; Goldbourt, U; Behar, S; Barchana, M; Wolf, I
PUB. DATE
June 2013
SOURCE
Prostate Cancer & Prostatic Diseases;Jun2013, Vol. 16 Issue 2, p181
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background:The worldwide incidence of diabetes mellitus is rapidly increasing. There is recent interest in the influence of glucose metabolism on oncogenesis. We investigated the role of diabetes mellitus and the metabolic syndrome (MS) on prostate cancer development.Methods:This study consisted of 11 541 men with coronary heart disease screened to participate in a secondary cardiac prevention trial. MS was defined according to modified NCEP/ATP III criteria. Multivariable regression analysis accounting for competing risks was performed using a modified Cox proportional hazard model in order to assess the association between diabetes, the MS and the subsequent development of prostate cancer.Results:At baseline, subjects were classified into one of the four groups: (1) 6119 (53%) with neither diabetic mellitus nor MS, (2) 3376 (29%) with the MS but without diabetes, (3) 560 (5%) with diabetes mellitus but without MS and (4) 1486 (13%) with both conditions. Median follow-up was 12.7 years (range 0-15.7 years). During follow-up, 459 new cases of prostate cancer were recorded. The age-adjusted hazard ratio (HR) for prostate cancer was reduced in diabetic patients compared with those without diabetes, 0.54 and 95% confidence interval of 0.40-0.73. No significant association was noted between the presence of MS and prostate cancer development. On multivariate analysis, diabetes mellitus continued to protect against the development of prostate cancer, this was more pronounced in the absence of MS (HR=0.43, P=0.01 for diabetes in the absence of MS; HR=0.64, P=0.08 in the presence of MS).Conclusions:The results of this study indicate an inverse association between type 2 diabetes mellitus and prostate cancer risk.
ACCESSION #
87580158

 

Related Articles

  • CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome. Lankinen, Maria A.; Hanhineva, Kati; Kolehmainen, Marjukka; Lehtonen, Marko; Auriola, Seppo; Mykkänen, Hannu; Poutanen, Kaisa; Schwab, Ursula; Uusitupa, Matti // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Objective: 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is a metabolite produced endogenously from dietary sources of furan fatty acids. The richest source of furan fatty acids in human diet is fish. CMPF was recently shown to be elevated in fasting plasma in individuals with...

  • Adiponectin complexes composition in Japanese- Brazilians regarding their glucose tolerance status. Crispim, Felipe; Vendramini, Marcio F.; Moisés, Regina S. // Diabetology & Metabolic Syndrome;2013, Vol. 5 Issue 1, p1 

    Background: Adiponectin circulates in different multimer complexes comprised of low molecular weight trimeric form (LMW), hexamer of middle molecular weight (MMW) and high molecular weight multimers (HMW). In Japanese-Brazilians, a population with high prevalence of glucose metabolism...

  • Effects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations. Perez-Martinez, Pablo; Perez-Caballero, Ana I.; Garcia-Rios, Antonio; Yubero-Serrano, Elena M.; Camargo, Antonio; Gomez-Luna, Maria J.; Marin, Carmen; Gomez-Luna, Purificacion; Dembinska-Kiec, Aldona; Rodriguez-Cantalejo, Fernando; Tinahones, Francisco J.; Roche, Helen M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose; Delgado-Lista, Javier; Clarke, Robert // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Background: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism....

  • Characterization of Former Gestational Diabetes Mellitus:Prognostic, Therapeutic, and Predictive Aspects. Tura, Andrea; Kautzky-Willer, Alexandra; Di Cianni, Graziano; Yogev, Yariv // International Journal of Endocrinology;2012, p1 

    In this article, the authors discuss various articles on pathophysiology of lipid and glucose metabolism in women with prior history of gestational diabetes mellitus, risk of developing type 2 diabetes and cardiovascular complications published in this issue of the periodical.

  • Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice. Jian Cai; Shuai Lu; Zheng Yao; Ya-Ping Deng; Ling-Di Zhang; Jia-Wen Yu; Guo-Fei Ren; Fu-Ming Shen; Guo-Jun Jiang // Cardiovascular Diabetology;2014, Vol. 13 Issue 1, p1 

    Sepsis is a common disease that continues to increase in incidence in the world. Diseases, such as diabetes, may make the situation worse. Diabetic patients are at increased risk for common infections. This study was designed to investigate the role of glibenclamide on myocardial injury by...

  • Impact of the Pro12Ala polymorphism of the PPAR?2 gene on diabetes and obesity in a highly consanguineous population. Abdulbari, Bener; Zirie, M.; Al-Hamaq, A. O. A. A.; Nawaz, Z.; Samson, N.; Mohammad, R. // Indian Journal of Endocrinology & Metabolism;Jan/Feb2015, Vol. 19 Issue 1, p77 

    Background: The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. It has been reported that they play important roles in obesity and the development of type 2 diabetes mellitus (T2DM). Materials and Methods: This...

  • Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study. Soriguer, F; Rojo-Martínez, G; Goday, A; Bosch-Comas, A; Bordiú, E; Caballero-Díaz, F; Calle-Pascual, A; Carmena, R; Casamitjana, R; Castaño, L; Castell, C; Catalá, M; Delgado, E; Franch, J; Gaztambide, S; Girbés, J; Gomis, R; Gutiérrez, G; López-Alba, A; Teresa Martínez-Larrad, M // European Journal of Clinical Nutrition;Sep2013, Vol. 67 Issue 9, p911 

    Background:Despite the marked increase in cardiovascular risk factors in Spain in recent years, the prevalence and incidence of cardiovascular diseases have not risen as expected. Our objective is to examine the association between consumption of olive oil and the presence of cardiometabolic...

  • Hyperglycaemia management of Type 2 Diabetes Mellitus inpatients in surgical wards at Livingstone Hospital. Jaram, Mohamed Khameez // South African Pharmaceutical Journal;2016, Vol. 83 Issue 8, p52 

    The article discusses hyperglycaemia management of type 2 diabetes mellitus (DM) inpatients in surgical wards at Livingstone Hospital. It says that three-and-a-half million South Africans, about 6% of the population, suffer from DM with several more probably undiagnosed. It adds that people with...

  • Metabolic syndrome among Caribbean-born persons living in the U.S. Virgin Islands. Tull, Eugene S.; Thurland, Anne; LaPorte, Ronald E. // Revista Panamericana de Salud Publica;Dec2005, Vol. 18 Issue 6, p418 

    Objectives. To determine the frequency of the metabolic syndrome (MS) among four subpopulations in the United States Virgin Islands and to estimate the risk for the MS that is associated with waist circumference cutpoints among overweight and obese individuals. Methods. In a study undertaken...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics