TITLE

Pluripotent stem cells for cardiac regeneration: Overview of recent advances & emerging trends

AUTHOR(S)
Pawani, Harsha; Bhartiya, Deepa
PUB. DATE
February 2013
SOURCE
Indian Journal of Medical Research;Feb2013, Vol. 137 Issue 2, p270
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cell based regenerative therapy has emerged as one of the most promising options of treatment for patients suffering from heart failure. Various adult stem cells types have undergone extensive clinical trials with limited success which is believed to be more of a cytokine effect rather than cell therapy. Pluripotent human embryonic stem cells (hESCs) have emerged as an attractive candidate stem cell source for obtaining cardiomyocytes (CMs) because of their tremendous capacity for expansion and unquestioned potential to differentiate into CMs. Studies carried out in animal models indicate that ES-derived CMs can partially remuscularize infarcted hearts and improve contractile function; however, the effect was not sustained over long follow up periods due to their limited capacity of cell division in vivo. Thus, the concept of transplanting multipotent cardiovascular progenitors derived from ES cells has emerged since the progenitors retain robust proliferative ability and multipotent nature enabling repopulation of other myocardial elements also in addition to CMs. Transplantation of CMs (progenitors) seeded in biodegradable scaffold and gel based engineered constructs has met with modest success due to issues like cell penetration, nutrient and oxygen availability and inflammation triggered during scaffold degradation inversely affecting the seeded cells. Recently cell sheet based tissue engineering involving culturing cells on 'intelligent' polymers has been evolved. Generation of a 3-D pulsatile myocardial tissue has been achieved. However, these advances have to be looked at with cautious optimism as many challenges need to be overcome before using these in clinical practice.
ACCESSION #
86930419

 

Related Articles

  • Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation. Cagavi, Esra; Bartulos, Oscar; Suh, Carol Y.; Sun, Baonan; Yue, Zhichao; Jiang, Zhengxin; Yue, Lixia; Qyang, Yibing // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    As heart failure due to myocardial infarction remains a leading cause of morbidity worldwide, cell-based cardiac regenerative therapy using cardiac progenitor cells (CPCs) could provide a potential treatment for the repair of injured myocardium. As adult CPCs may have limitations regarding...

  • Cardiac Cell Therapies: The Next Generation. Choi, Yeong-Hoon; Saric, Tomo; Nasseri, Boris; Hühn, Stefan; Van Linthout, Sophie; Hetzer, Roland; Tschöpe, Carsten; Stamm, Christof // Cardiovascular Therapeutics;Feb2011, Vol. 29 Issue 1, p2 

    Although significant advances have been made in terms of pharmacological, catheter-based, and surgical palliation, heart failure remains a fatal disease. As a curative concept, regenerative medicine aims at the restoration of the physiologic cellular composition of diseased organs. So far,...

  • SSEA-4+ CD34- Cells in the Adult Human Heart Show the Molecular Characteristics of a Novel Cardiomyocyte Progenitor Population. Sandstedt, Joakim; Jonsson, Marianne; Vukusic, Kristina; Dellgren, Göran; Lindahl, anders; Jeppsson, anders; asp, Julia // Cells Tissues Organs;Dec2014, Vol. 199 Issue 2/3, p103 

    Stage-specific embryonic antigen (SSEA) expression is used to describe the differentiation state of an embryonic stem cell (ESC). In human ESCs, SSEA-3 and SSEA-4 are highly expressed in undifferentiated cells and downregulated upon differentiation. SSEA-4 has also been described as a marker for...

  • Cardiomyocyte culture - an update on the in vitro cardiovascular model and future challenges. Parameswaran, Sreejit; Kumar, Sujeet; Verma, Rama Shanker; Sharma, Rajendra K. // Canadian Journal of Physiology & Pharmacology;Dec2013, Vol. 91 Issue 12, p985 

    The success of any work with isolated cardiomyocytes depends on the reproducibility of cell isolation, because the cells do not divide. To date, there is no suitable in vitro model to study human adult cardiac cell biology. Although embryonic stem cells and induced pluripotent stem cells are...

  • A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Später, Daniela; Abramczuk, Monika K.; Buac, Kristina; Zangi, Lior; Stachel, Maxine W.; Clarke, Jonathan; Sahara, Makoto; Ludwig, Andreas; Chien, Kenneth R. // Nature Cell Biology;Sep2013, Vol. 15 Issue 9, p1098 

    Most of the mammalian heart is formed from mesodermal progenitors in the first and second heart fields (FHF and SHF), whereby the FHF gives rise to the left ventricle and parts of the atria and the SHF to the right ventricle, outflow tract and parts of the atria. Whereas SHF progenitors have...

  • Isolation, Culture and Characterization of Cardiac Progenitor Cells Derived from Human Embryonic Heart Tubes. Zhang, Xi; Zhang, Chuan-Sen; Liu, Yan-Chun; Yang, Xiang-Qun; Xiong, Shao-Hu; Wen, Yu; Jiang, Er-Peng; Li, Rui; Zhang, Zhi-Ying; Liu, Fang; Ye, Yong // Cells Tissues Organs;Dec2017, Vol. 204 Issue 7, p194 

    A variety of studies have reported on the isolation and expansion of cardiac stem cells from adult hearts. However, there is little information concerning cardiac stem/progenitor cells derived from embryonic hearts/heart tubes. To provide more evidence for embryonic heart-derived stem/progenitor...

  • MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes. Wagh, Vilas; Pomorski, Alexander; Wilschut, Karlijn J.; Piombo, Sebastian; Bernstein, Harold S. // Stem Cell Research & Therapy;2014, Vol. 5 Issue 3, p1 

    Introduction Posttranscriptional control of mRNA by microRNA (miRNA) has been implicated in the regulation of diverse biological processes from directed differentiation of stem cells through organism development. In this study we describe a unique pathway by which miRNA regulate the specialized...

  • Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro. Heng, Boon Chin; Haider, Husnain Kh; Sim, Eugene Kwang-Wei; Cao, Tong; Ng, Soon Chye // Cardiovascular Research;Apr2004, Vol. 62 Issue 1, p34 

    Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to...

  • Natural and Synthetic Regulators of Embryonic Stem Cell Cardiogenesis. Willems, Erik; Bushway, Paul J.; Mercola, Mark // Pediatric Cardiology;Jul2009, Vol. 30 Issue 5, p635 

    Debilitating cardiomyocyte loss underlies the progression to heart failure. Although there have been significant advances in treatment, current therapies are intended to improve or preserve heart function rather than regenerate lost myocardium. A major hurdle in implementing a cell-based...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics