Ulososides and Urabosides - Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox

Colorado, Jhonny; Muñoz, Diana; Marquez, Diana; Marquez, Maria Elena; Lopez, Juan; Thomas, Olivier P.; Martinez, Alejandro
March 2013
Molecules;Mar2013, Vol. 18 Issue 3, p2598
Academic Journal
Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3), together with the previously reported ulososide A (4), were isolated from the Caribbean marine sponge Ectyoplasia ferox. Their structures were elucidated using extensive interpretation of 1D and 2D-NMR data, as well as HRESIMS. The aglycon of all compounds is a rare 30-norlonastane and the sugar residues were identified after acid hydrolysis and GC analyses. Cytotoxicities of the isolated compounds were evaluated against Jurkat and CHO cell lines by a MTT in vitro assay as well as a hemolysis assay. Unexpectedly, all these saponin derivatives showed very low activity in our bioassays.


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