Insight to neoplastic thyroid lesions by fine needle aspiration cytology

Rangaswamy, M; Narendra, Kl; Patel, S; Gururajprasad, C; Manjunath, Gv
January 2013
Journal of Cytology;Jan-Mar2013, Vol. 30 Issue 1, p23
Academic Journal
Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre‑operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions. Aim: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study. Materials and Methods: 100 cases of thyroid FNAC smears were analyzed and cyto‑histopathological correlation was done in 47 cases. Galen and Gambino’s method was used to calculate the sensitivity and positive predictive value. Results: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non‑neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions. Conclusions: FNAC is a rapid, efficient, cost‑effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.


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