TITLE

Virgin birth: engineered heart muscle from parthenogenetic stem cells

AUTHOR(S)
McSweeney, Sara J.; Schneider, Michael D.
PUB. DATE
March 2013
SOURCE
Journal of Clinical Investigation;Mar2013, Vol. 123 Issue 3, p1010
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cardiac muscle restitution, or true regeneration, is an unmet need in the treatment of myocardial infarction (MI), prompting a decade of study with stem cells of many kinds. Among key obstacles to effective cardiac cell grafting are the cost of autologous stem cell-derived cardiomyocytes, the ethical implications of using embryonic stem cell (ESC) products, immunological barriers to allogeneic cells, functional maturation beyond just the correct lineage decision, and the lack of durable engraftment. In this issue of the JCI, Didié and colleagues show that cardiomyocytes made from parthenogenetic stem cells (PSCs) and deployed as engineered heart muscle (EHM) may overcome all of these formidable barriers.
ACCESSION #
85973865

 

Related Articles

  • Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro. Heng, Boon Chin; Haider, Husnain Kh; Sim, Eugene Kwang-Wei; Cao, Tong; Ng, Soon Chye // Cardiovascular Research;Apr2004, Vol. 62 Issue 1, p34 

    Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to...

  • Human Embryonic Stem Cell-Derived Cardiomyocytes for Heart Therapies. Chung Wah Siu; Moore, Jennifer C.; Li, Ronald A. // Cardiovascular & Haematological Disorders - Drug Targets;Jun2007, Vol. 7 Issue 2, p145 

    Cardiovascular diseases remain the leading cause of mortality and morbidity worldwide. Despite substantial improvements in acute management, survivors of myocardial infarction often progress to heart failure. Since adult cardiomyocytes (CMs) do not regenerate, their loss permanently compromises...

  • Antiapoptotic Effect of Implanted Embryonic Stem Cell-Derived Early-Differentiated Cells in Aging Rats After Myocardial Infarction. Meixiang Xiang; Jianan Wang; Kaplan, Emel; Oettgen, Peter; Lipsitz, Lewis; Morgan, James P.; Jiang-Yong Min // Journals of Gerontology Series A: Biological Sciences & Medical ;Dec2006, Vol. 61 Issue 12, p1219 

    This study tested whether implanted embryonic stem cell-derived early-differentiated cells (EDCs) lead to improvement in cardiac function by preventing cardiac apoptosis in aging rats after myocardial infarction. Cardiac apoptosis after transplantation of EDCs was assessed in situ by terminal...

  • Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Zhang, Qiangzhe; Jiang, Junjie; Han, Pengcheng; Yuan, Qi; Zhang, Jing; Zhang, Xiaoqian; Xu, Yanyan; Cao, Henghua; Meng, Qingzhang; Chen, Li; Tian, Tian; Wang, Xin; Li, Pu; Hescheler, Jurgen; Ji, Guangju; Ma, Yue // Cell Research;Apr2011, Vol. 21 Issue 4, p579 

    Although myocyte cell transplantation studies have suggested a promising therapeutic potential for myocardial infarction, a major obstacle to the development of clinical therapies for myocardial repair is the difficulties associated with obtaining relatively homogeneous ventricular myocytes for...

  • Donor Mesenchymal Stromal Cells (MSCs) Undergo Variable Cardiac Reprogramming in Vivo and Predominantly Co-Express Cardiac and Stromal Determinants after Experimental Acute Myocardial Infarction. Yannarelli, Gustavo; Tsoporis, James; Desjardins, Jean-Francois; Wang, Xing; Pourdjabbar, Ali; Viswanathan, Sowmya; Parker, Thomas; Keating, Armand // Stem Cell Reviews & Reports;Apr2014, Vol. 10 Issue 2, p304 

    We previously showed the emergence of predominantly non-fused murine cells co-expressing cardiac and stromal determinants in co-cultures of murine mesenchymal stromal cells (MSCs) and rat embryonic cardiomyocytes. To determine whether a similar phenotype is detectable in vivo in ischemic...

  • Human embryonic stem cells: towards therapies for cardiac disease. Derivation of a Dutch human embryonic stem cell line. van de Stolpe, Anja; van De Brink, Stieneke; van Rooijen, Marga; Ward-van Oostwaard, Dorien; van Inzen, Wouter; Slaper-Cortenbach, Ineke; Fauser, Bart; van den Hout, Nijske; Weima, Sjerp; Passier, Robert; Smith, Nigel; Dening, Chris; Mummery, Christine // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Oct2005, Vol. 11 Issue 4, p476 

    Cell transplantation is being discussed as a potential therapy for multiple disorders caused by loss or malfunction of single or at most a few cell types. These include diabetes. Parkinson's disease and myocardial infarction or cardiac failure. However, it is not yet clear whether cells from...

  • A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. Blin, Guillaume; Nury, David; Stefanovic, Sonia; Tui Neri; Guillevic, Oriane; Brinon, Benjamin; Bellamy, Valérie; Rücker-Martin, Catherine; Barbry, Pascal; Bel, Alain; Bruneval, Patrick; Cowan, Chad; Pouly, Julia; Mitalipov, Shoukhrat; Gouadon, Elodie; Binder, Patrice; Hagège, Albert; Desnos, Michel; Renaud, Jean-François; Menasché, Philippe // Journal of Clinical Investigation;Apr2010, Vol. 120 Issue 4, p1125 

    Cell therapy holds promise for tissue regeneration, including in individuals with advanced heart failure. However, treatment of heart disease with bone marrow cells and skeletal muscle progenitors has had only marginal positive benefits in clinical trials, perhaps because adult stem cells have...

  • Human embryonic stem cell transplantation to repair the infarcted myocardium. Leor, Jonathan; Gerecht, Sharon; Cohen, Smadar; Miller, Liron; Holbova, Radka; Ziskind, Anna; Shachar, Michal; Feinberg, Micha S.; Guetta, Esther; Itskovitz-Eldor, Joseph // Heart;Oct2007, Vol. 93 Issue 10, p1278 

    9Objective: To test the hypothesis that human embryonic stem cells (hESCs) can be guided to form new myocardium by transplantation into the normal or infarcted heart, and to assess the influence of hESC-derived cardiomyocytes (hESCMs) on cardiac function in a rat model of myocardial infarction...

  • Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation. Cagavi, Esra; Bartulos, Oscar; Suh, Carol Y.; Sun, Baonan; Yue, Zhichao; Jiang, Zhengxin; Yue, Lixia; Qyang, Yibing // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    As heart failure due to myocardial infarction remains a leading cause of morbidity worldwide, cell-based cardiac regenerative therapy using cardiac progenitor cells (CPCs) could provide a potential treatment for the repair of injured myocardium. As adult CPCs may have limitations regarding...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics