TITLE

Genome-Wide Association Study Heterogeneous Cohort Homogenization via Subject Weight Knock-Down

AUTHOR(S)
Valente, André X. C. N.; Zischkau, Joseph; Joo Heon Shin; Gao, Yuan; Sarkar, Abhijit
PUB. DATE
October 2012
SOURCE
PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing the statistical weight of selected individuals. After homogenization, the cohort is statistically handled as if originating from a single well-mixed population. The method was applied to homogenize a Parkinson's disease genome-wide association study cohort.
ACCESSION #
83524453

 

Related Articles

  • UCLA Scientists Image How Parkinson's Genes Misfire in Mice; May Help Identify Genes for Autism, Schizophrenia.  // Ascribe Newswire: Health;5/29/2002, p10 

    This article reports on the development, by UCLA scientists published in the June 2001 edition of the periodical "Genome Research," of a fast new way to image how thousands of genes misfire proteins in a mouse model of Parkinson's disease. The approach may provide a research blueprint for...

  • PARK16 haplotypes and the importance of protective genetic factors in Parkinson's disease. Gan-Or, Ziv // Journal of Human Genetics;Aug2015, Vol. 60 Issue 8, p461 

    No abstract available.

  • Neurophysiology of Drosophila Models of Parkinson’s Disease. West, Ryan J. H.; Furmston, Rebecca; Williams, Charles A. C.; Elliott, Christopher J. H. // Parkinson's Disease (20420080);4/20/2015, Vol. 2015, p1 

    We provide an insight into the role Drosophila has played in elucidating neurophysiological perturbations associated with Parkinson’s disease- (PD-) related genes. Synaptic signalling deficits are observed in motor, central, and sensory systems. Given the neurological impact of disease...

  • Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease. Simón-Sánchez, Javier; Kilarski, Laura L.; Nalls, Michael A.; Martinez, Maria; Schulte, Claudia; Holmans, Peter; Gasser, Thomas; Hardy, John; Singleton, Andrew B.; Wood, Nicholas W.; Brice, Alexis; Heutink, Peter; Williams, Nigel; Morris, Huw R. // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Parkinson's disease (PD) occurs in both familial and sporadic forms, and both monogenic and complex genetic factors have been identified. Early onset PD (EOPD) is particularly associated with autosomal recessive (AR) mutations, and three genes, PARK2, PARK7 and PINK1, have been found to carry...

  • Joint Rare Variant Association Test of the Average and Individual Effects for Sequencing Studies. Yuanjia Wang; Yin-Hsiu Chen; Qiong Yang // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    For many complex traits, single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) only explain a small percentage of heritability. Next generation sequencing technology makes it possible to explore unexplained heritability by identifying rare variants (RVs)....

  • Population genomics of human gene expression. Stranger, Barbara E.; Nica, Alexandra C.; Forrest, Matthew S.; Dimas, Antigone; Bird, Christine P.; Beazley, Claude; Ingle, Catherine E.; Dunning, Mark; Flicek, Paul; Koller, Daphne; Montgomery, Stephen; Tavaré, Simon; Deloukas, Panos; Dermitzakis, Emmanouil T. // Nature Genetics;Oct2007, Vol. 39 Issue 10, p1217 

    Genetic variation influences gene expression, and this variation in gene expression can be efficiently mapped to specific genomic regions and variants. Here we have used gene expression profiling of Epstein-Barr virus–transformed lymphoblastoid cell lines of all 270 individuals genotyped...

  • Genome-wide strategies for detecting multiple loci that influence complex diseases. Marchini, Jonathan; Donnelly, Peter; Cardon, Lon R // Nature Genetics;Apr2005, Vol. 37 Issue 4, p413 

    After nearly 10 years of intense academic and commercial research effort, large genome-wide association studies for common complex diseases are now imminent. Although these conditions involve a complex relationship between genotype and phenotype, including interactions between unlinked loci, the...

  • MISS: a non-linear methodology based on mutual information for genetic association studies in both population and sib-pairs analysis. Brunel, Helena; Gallardo-Chacón, Joan-Josep; Buil, Alfonso; Vallverdú, Montserrat; Soria, José Manuel; Caminal, Pere; Perera, Alexandre // Bioinformatics;Aug2010, Vol. 26 Issue 15, p1811 

    Motivation: Finding association between genetic variants and phenotypes related to disease has become an important vehicle for the study of complex disorders. In this context, multi-loci genetic association might unravel additional information when compared with single loci search. The main goal...

  • Sequence-Level Population Simulations Over Large Genomic Regions. Hoggart, Clive J.; Chadeau-Hyam, Marc; Clark, Taane G.; Lampariello, Riccardo; Whittaker, John C.; De Iorio, Maria; Balding, David J. // Genetics;Nov2007, Vol. 177 Issue 3, p1725 

    Simulation is an invaluable tool for investigating the effects of various population genetics modeling assumptions on resulting patterns of genetic diversity, and for assessing the performance of statistical techniques, for example those designed to detect and measure the genomic effects of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics