In Shape - The Art of Mapping Conformational Epitopes

Gadermaier, Elisabeth
March 2012
International Archives of Allergy & Immunology;Mar2012, Vol. 157 Issue 4, p321
Academic Journal
No abstract available Copyright © 2010 S. Karger AG, Basel


Related Articles

  • Circumscribing the Conformational Peptide Epitope Landscape. Lucchese, Guglielmo; Calabro', Michele; Kanduc, Darja // Current Pharmaceutical Design;2/21/2012, Vol. 18 Issue 6, p832 

    The development of vaccines for new and re-emerging pathologies and infections is based on the ability to define immunogenic epitopes. An immunogenic B-cell peptide epitope is a specific restricted antigen region that is capable of eliciting a humoral immune response and of combining with a...

  • .Application of circular consensus sequencing and network analysis to characterize the bovine IgG repertoire. Larsen, Peter A.; Smith, Timothy P. L. // BMC Immunology;2012, Vol. 13 Issue 1, p52 

    Background: Vertebrate immune systems generate diverse repertoires of antibodies capable of mediating response to a variety of antigens. Next generation sequencing methods provide unique approaches to a number of immuno-based research areas including antibody discovery and engineering, disease...

  • Cationic antimicrobial peptides in clinical development, with special focus on thanatin and heliomicin. Andrès, E. // European Journal of Clinical Microbiology & Infectious Diseases;Jun2012, Vol. 31 Issue 6, p881 

    Cationic host-defence antimicrobial peptides are recognised as an important component of the innate immune response in most multicellular organisms. In humans, several antimicrobial peptides have recently been recognised as key factors in the pathology of diseases such as cystic fibrosis, septic...

  • Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis. Aravind, L.; de Souza, Robson F.; Iyer, Lakshminarayan M. // Biology Direct;2010, Vol. 5, p48 

    Background: Recent studies point to a great diversity of non-ribosomal peptide synthesis systems with major roles in amino acid and co-factor biosynthesis, secondary metabolism, and post-translational modifications of proteins by peptide tags. The least studied of these systems are those...

  • Peptides of the Constant Region of Antibodies Display Fungicidal Activity. Polonelli, Luciano; Ciociola, Tecla; Magliani, Walter; Zanello, Pier Paolo; D'Adda, Tiziana; Galati, Serena; De Bernardis, Flavia; Arancia, Silvia; Gabrielli, Elena; Pericolini, Eva; Vecchiarelli, Anna; Arruda, Denise C.; Pinto, Marcia R.; Travassos, Luiz R.; Pertinhez, Thelma A.; Spisni, Alberto; Conti, Stefania // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia...

  • Substrate-Specific Gene Expression in Batrachochytrium dendrobatidis, the Chytrid Pathogen of Amphibians. Rosenblum, Erica Bree; Poorten, Thomas J.; Joneson, Suzanne; Settles, Matthew // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    Determining the mechanisms of host-pathogen interaction is critical for understanding and mitigating infectious disease. Mechanisms of fungal pathogenicity are of particular interest given the recent outbreaks of fungal diseases in wildlife populations. Our study focuses on Batrachochytrium...

  • Genetic variability of MHC class II DQB exon 2 alleles in yak ( Bos grunniens). He, Yiduo; Xi, Dongmei; Leng, Jing; Qian, Tao; Jin, Dan; Chen, Ting; Yang, Chunling; Hao, Tiantian; Yang, Zaiqing; Deng, Weidong // Molecular Biology Reports;Apr2014, Vol. 41 Issue 4, p2199 

    The major histocompatibility class (MHC) DQ molecules are dimeric glycoproteins revealing antigen presentation to CD T cells. In the present study, the exon 2 of the MHC class II DQB gene from 32 yaks ( Bos grunniens) was cloned, sequenced and compared with previously reported patterns for other...

  • The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site. Stickler, M M; Reddy, A; Xiong, J M; Hinton, P R; DuBridge, R; Harding, F A // Genes & Immunity;Apr2011, Vol. 12 Issue 3, p213 

    The human G1m1 allotype comprises two amino acids, D12 and L14, in the CH3 domain of IGHG1. Although the G1m1 allotype is prevalent in human populations, ∼40% of Caucasiods are homozygous for the nG1m1 allotype corresponding to E12 and M14. Peptides derived from the G1m1 region were tested...

  • Structural biology of moonlighting: lessons from antibodies. Martin, Andrew C. R. // Biochemical Society Transactions;Dec2014, Vol. 42 Issue 6, p1704 

    Protein moonlighting is the property of a number of proteins to have more than one function. However, the definition of moonlighting is somewhat imprecise with different interpretations of the phenomenon. True moonlighting occurs when an individual evolutionary protein domain has one...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics