Risk Factors for Non-Hodgkin's Lymphomas in Acquired Immunodeficiency Syndrome (AIDS)

Armenian, Haroutune K.; Hoover, Donald R.; Rubb, Susan; Metz, Sharon; Martinez-Maza, Otoniel; Chmiel, Joan; Kingsley, Lawrence; Saah, Alfred
January 1996
American Journal of Epidemiology;1996, Vol. 143 Issue 4, p374
Academic Journal
The possibility that an agent in addition to the human immunodeficiency virus (HIV) may contribute to the etiology of non-Hodgkin's lymphoma in persons with acquired immunodeficiency syndrome (AIDS) was studied using participants from the Multicenter AIDS Cohort Study (MACS) of homosexual and bisexual men enrolled in 1984–1985 and also in 1987–1991. A nested case-control analysis was conducted. The primary source of information on potential exposures and characteristics of the participants was the baseline study entry interview that was conducted prior to the development of AIDS. A total of 84 cases of non-Hodgkin's lymphoma were identified and compared with 527 participants who developed AIDS but had no evidence of cancer. The groups were similar for most sociodemographic characteristics as well as sexual activity and past history of antecedent illnesses. Although the non-Hodgkin's lymphoma cases reported less frequent use of recreational drugs and cigarettes compared with other persons with AIDS, these differences were not significant. Non-Hodgkin's lymphoma cases reported more frequent intake of aspirin during the week before the interview. However, there were no differences between the comparison groups for long-term aspirin intake or intake of other analgesics. The absence of any specific and strong association between non-Hodgkin's lymphoma and the various behavior-related activities and exposures considered in this analysis suggests that these factors are not related to a second agent in the etiology of HIV-induced non-Hodgkin's lymphoma. The possibility that a very common agent in this study population or that differences in the nature of the immune dysfunction resulting from HIV infection could act as a cofactor for HIV-induced non-Hodgkin's lymphoma cannot be excluded.


Related Articles

  • Development of non-Hodgkin lymphoma in a cohort of patients with severe human immunodeficiency virus (HIV) infection on long-term antiretroviral therapy. Pluda, James M.; Yarchoan, Robert; Jaffe, Elaine S.; Feuerstein, Irwin M.; Solomon, Diane; Steinberg, Seth M.; Wyvill, Kathleen M.; Raubitschek, Andrew; Katz, David; Broder, Samuel; Pluda, J M; Yarchoan, R; Jaffe, E S; Feuerstein, I M; Solomon, D; Steinberg, S M; Wyvill, K M; Raubitschek, A; Katz, D; Broder, S // Annals of Internal Medicine;8/15/90, Vol. 113 Issue 4, p276 

    Objective: To describe the incidence of non-Hodgkin lymphoma in a group of patients with symptomatic human immunodeficiency virus (HIV) infection receiving long-term dideoxynucleoside antiretroviral therapy.Design: We examined the records of all patients with the...

  • LINFOMAS ASOCIADOS CON LA INFECCION POR EL VIRUS DE LA INMUNODEFICIENCIA HUMANA: SUBTIPOS HISTOLOGICOS Y ASOCIACION CON LOS VIRUS DE EPSTEIN BARR Y HERPES-8. Corti, Marcelo; De Dios Soler, Marcela; Bare, Patricia; Villafañe, Maria F.; De Tezanos Pinto, Miguel; Bianco, Raul Perez; Narbaitz, Marina // Medicina (Buenos Aires);2010, Vol. 70 Issue 2, p151 

    Non-Hodgkin lymphomas (NHL) of the B-cell type are the second most common neoplasm among patients with human immunodeficiency virus (HIV) infection and AIDS. Here, we evaluated 48 cases of AIDS-related lymphomas (ARL) diagnosed at the Histopathological Division of the Instituto de...

  • Opportunistic Non-Hodgkin's Lymphomas Among Severely Immunocompromised HIV-Infected Patients Surviving for Prolonged Periods on Antiretroviral Therapy--United States.  // JAMA: Journal of the American Medical Association;9/25/91, Vol. 266 Issue 12, p1620 

    Characterizes the occurrence of non-Hodgkin's lymphomas (NHL) in a cohort of persons with AIDS or severe HIV infection who have received long-term zidovudine-based therapy. Estimated probability of developing NHL within 24 months of initiating antiretroviral therapy; Percentage increase in the...

  • Increased incidence of Hodgkin disease in homosexual men with HIV infection. Hessol, Nancy A.; Katz, Mitchell H.; Liu, Jennifer Y.; Buchbinder, Susan P.; Rubino, Christopher J.; Holmberg, Scott D.; Hessol, N A; Katz, M H; Liu, J Y; Buchbinder, S P; Rubino, C J; Holmberg, S D // Annals of Internal Medicine;8/15/92, Vol. 117 Issue 4, p309 

    Objective: To evaluate the incidence of Hodgkin disease and non-Hodgkin lymphoma among homosexual men infected with human immunodeficiency virus (HIV).Design: Cohort study with computer-matched identification of participants with the Northern California Cancer Center...

  • Linfomas con afectación hepática en pacientes con sida. Características clínicas e histopatológicas en cinco pacientes y revisión de la bibliografía. Corti, Marcelo; Metta, Humberto; VillafaÁe, María F.; Trione, Norberto; Bistman, Alicia; Schtirbu, Ricardo; Narbaitz, Marina // Patologia Revista Latinoamericana;ene-mar2009, Vol. 47 Issue 1, p25 

    Background: Non-Hodgkin's lymphoma (NHL) of the B-cell type is the second most common neoplasm among patients with human immunodeficiency virus infection (HIV) and AIDS. The high frequency of extranodal involvement is one of the major clinical characteristics of AIDS-associated NHL. Highly...

  • Fine-needle aspiration biopsy of patients with acquired immunodeficiency syndrome (AIDS): experience in an outpatient clinic. Bottles, Kent; McPhaul, Laron W.; Volberding, Paul; Bottles, K; McPhaul, L W; Volberding, P // Annals of Internal Medicine;Jan88, Vol. 108 Issue 1, p42 

    One hundred twenty-one fine-needle aspiration biopsies of lymph nodes were done on 113 men followed in the AIDS (acquired immunodeficiency syndrome) Outpatient Clinic of the San Francisco General Hospital. The cytologic diagnoses on these 121 biopsies included 60 (50%) hyperplasias, 24 (20%)...

  • EBV, HHV8 and HIV in B cell non Hodgkin lymphoma in Kampala, Uganda. Tumwine, Lynnette K.; Orem, Jackson; Kerchan, Patrick; Byarugaba, Wilson; Pileri, Stefano A. // Infectious Agents & Cancer;2010, Vol. 5, p12 

    Background: B cell non Hodgkin lymphomas account for the majority of lymphomas in Uganda. The commonest is endemic Burkitt lymphoma, followed by diffuse large-B-cell lymphoma (DLBCL). There has been an increase in incidence of malignant lymphoma since the onset of the HIV/AIDS pandemic. However,...

  • AIDS increases stomach, esophageal cancer risks.  // Hem/Onc Today;11/10/2012, Vol. 13 Issue 21, p22 

    The article reports on the results of a study, which used the human immunodeficiency virus/acquired immune deficiency syndrome (AIDS) Cancer Match Study, claiming that AIDS patients are more likely than the general population to acquire stomach or esophageal carcinomas and non-Hodgkin's lymphomas.

  • Hodgkin's lymphoma in an HIV-positive man. Blaes, Anne // Hem/Onc Today;12/25/2008, Vol. 9 Issue 23, p14 

    The article describes the case of Hodgkin's lymphoma in a human immunodeficiency virus (HIV)-positive man. Hodgkins lymphoma is increased in persons with HIV/acquire immune deficiency syndrome (AIDS). Risks are increased from fivefold to 15-fold. Hodgkin's lymphoma is more common among...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics