Prognostic Significance of Neuroendocrine Differentiation in Prostate Adenocarcinoma

Sagnak, Levent; Topaloglu, Hikmet; Ozok, Ugur; Ersoy, Hamit
September 2012
European Journal of Clinical & Medical Oncology;2012, Vol. 4 Issue 3, p7
Academic Journal
Much progress has been made towards an understanding of the development and progression of prostate cancer (PC), and the factors which drive the development of androgen independence. Neuroendocrine (NE) cells may provide an intriguing link between NE cell differentiation (NED) and tumor progression in PC. NED in PC generally confers a more aggressive clinical behavior and less favorable prognosis than usual PC. In this article, we will review the known functions of NE cells in PC and will discuss our current knowledge on stimulation of cancer proliferation, invasion, apoptosis resistance, serum, and immunohistochemical markers and the prognostic significance of NED in human PC


Related Articles

  • CAV3.1 knockdown suppresses cell proliferation, migration and invasion of prostate cancer cells by inhibiting AKT. Hu, Shanbiao; Li, Ling; Huang, Wei; Liu, Jie; Lan, Gongbin; Yu, Shaojie; Peng, Longkai; Xie, Xubiao; Yang, Luoyan; Nian, Yeqi; Wang, Yinhuai // Cancer Management & Research;Oct2018, Vol. 10, p4603 

    Background: Aberrant expression of CAV3.1, one of T-type Ca2+ channels, is reported to exert important functions in pathological processes, including carcinogenesis. However, its expression pattern and function in prostate cancer (PCa) remains unclear.Materials and methods: The expression...

  • Prognostic Significance of Neuroendocrine Differentiation in Prostate Adenocarcinoma. Sagnak, Levent; Topaloglu, Hikmet; Ozok, Ugur; Ersoy, Hamit // European Journal of Clinical & Medical Oncology;2011, Vol. 3 Issue 4, p84 

    Much progress has been made towards an understanding of the development and progression of prostate cancer (PC), and the factors which drive the development of androgen independence. Neuroendocrine (NE) cells may provide an intriguing link between NE cell differentiation (NED) and tumor...

  • Dual specificity phosphatase 6 suppresses the growth and metastasis of prostate cancer cells. XIAOLEI ZHAI; QIANHE HAN; ZHONGJIE SHAN; XIAOWEI QU; LIANG GUO; YUDONG ZHOU // Molecular Medicine Reports;2014, Vol. 10 Issue 6, p3052 

    Dual specificity phosphatase 6 (DUSP6) is expressed at low levels in numerous types of human cancer. The loss of DUSP6 plays a pivotal role in tumor progression; however, the role of DUSP6 in prostate cancer remains unclear. In this study, in vitro invasion assays and in vivo metastasis...

  • Cardiolipin composition correlates with prostate cancer cell proliferation. Sapandowski, Anja; Stope, Matthias; Evert, Katja; Evert, Matthias; Zimmermann, Uwe; Peter, Daniela; Päge, Ilona; Burchardt, Martin; Schild, Lorenz // Molecular & Cellular Biochemistry;Dec2015, Vol. 410 Issue 1/2, p175 

    Prostate cancer (PC) is the second most diagnosed cancer in men. It has been recognized that diet can play a crucial role in PC genesis and progression. In this context, free fatty acids are considered as modulators of cell proliferation. Recently, a relationship between the composition of the...

  • B7-H1 Expression Is Associated with Poor Prognosis in Colorectal Carcinoma and Regulates the Proliferation and Invasion of HCT116 Colorectal Cancer Cells. Shi, Sheng-Jia; Wang, Li-Juan; Wang, Guo-Dong; Guo, Zhang-Yan; Wei, Ming; Meng, Yan-Ling; Yang, An-Gang; Wen, Wei-Hong // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Background And Objective:The investigation concerning the B7-H1 expression in colorectal cancer cells is at an early stage. It is unclear whether B7-H1 expression may have diagnostic or prognostic value in colorectal carcinoma. Additionally, how B7-H1 is associated with the clinical features of...

  • Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters. Melling, Nathaniel; Thomsen, Erik; Tsourlakis, Maria Christina; Kluth, Martina; Hube-Magg, Claudia; Minner, Sarah; Koop, Christina; Graefen, Markus; Heinzer, Hans; Wittmer, Corinna; Sauter, Guido; Wilczak, Waldemar; Huland, Hartwig; Simon, Ronald; Schlomm, Thorsten; Steurer, Stefan; Krech, Till // Carcinogenesis;Nov2015, Vol. 36 Issue 11, p1333 

    Enhancer of zeste homolog 2 (EZH2) plays an important role in tumor development and progression by interacting with histone and nonhistone proteins. In the current study, we analyzed prevalence and prognostic impact of EZH2 in prostate cancer. EZH2 expression was analyzed by immunohistochemistry...

  • The expression and functional role of FOX transcription factor FOXJ1 in prostate cancer. Qi An; Dezhong Liu; Lian Zou // International Journal of Clinical & Experimental Medicine;2017, Vol. 10 Issue 1, p285 

    As one common malignant tumor in male reproductive-urinary system, the incidence of prostate cancer is increasing rapidly. Recent study revealed the participation of FOX transcription factor family in tumor occurrence and progression. FOXJ1, one member of FOX family, plays an important role in...

  • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Lunardi, Andrea; Ala, Ugo; Epping, Mirjam T; Salmena, Leonardo; Clohessy, John G; Webster, Kaitlyn A; Wang, Guocan; Mazzucchelli, Roberta; Bianconi, Maristella; Stack, Edward C; Lis, Rosina; Patnaik, Akash; Cantley, Lewis C; Bubley, Glenn; Cordon-Cardo, Carlos; Gerald, William L; Montironi, Rodolfo; Signoretti, Sabina; Loda, Massimo; Nardella, Caterina // Nature Genetics;Jul2013, Vol. 45 Issue 7, p747 

    Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a Pten loss-driven mouse model...

  • Thrombospondin-1-derived 4N1K peptide expression is negatively associated with malignant aggressiveness and prognosis in urothelial carcinoma of the upper urinary tract. Miyata, Yasuyoshi; Watanabe, Shin-ichi; Kanetake, Hiroshi; Sakai, Hideki // BMC Cancer;2012, Vol. 12 Issue 1, p372 

    Background: Thrombospondin (TSP) is a multi-functional protein that appears to have dual roles in cancer, that is,either as a promoter or a suppressor. 4N1K is a TSP-derived peptide that has been reported to be associated with neovascularity, cell survival, and invasion. There is a little...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics