TITLE

Prognostic Significance of Neuroendocrine Differentiation in Prostate Adenocarcinoma

AUTHOR(S)
Sagnak, Levent; Topaloglu, Hikmet; Ozok, Ugur; Ersoy, Hamit
PUB. DATE
September 2012
SOURCE
European Journal of Clinical & Medical Oncology;2012, Vol. 4 Issue 3, p7
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Much progress has been made towards an understanding of the development and progression of prostate cancer (PC), and the factors which drive the development of androgen independence. Neuroendocrine (NE) cells may provide an intriguing link between NE cell differentiation (NED) and tumor progression in PC. NED in PC generally confers a more aggressive clinical behavior and less favorable prognosis than usual PC. In this article, we will review the known functions of NE cells in PC and will discuss our current knowledge on stimulation of cancer proliferation, invasion, apoptosis resistance, serum, and immunohistochemical markers and the prognostic significance of NED in human PC
ACCESSION #
80415999

 

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