2010 - Meta-analysis: Aspirin reduces risk for colon cancer and related mortality at 20 years, particularly when taken for greater than or equal to 5 years

Koretz, Ronald
March 2011
ACP Journal Club;3/20/2011, Vol. 154 Issue 3, p2
Academic Journal
Question Does aspirin reduce risk for colorectal cancer and related mortality in the long term? Scope Included trials were done in the UK or Sweden in the 1980s and early 1990s and compared aspirin with control, had >1000 participants, and had a median scheduled treatment period >2.5 years. Outcomes were colorectal cancer incidence and mortality. Methods 5 randomized controlled trials (RCTs) met the selection criteria: 4 compared aspirin with control for primary (Thrombosis Prevention Trial, British Doctors Aspirin Trial) or secondary (Swedish Aspirin Low Dose Trial, UK-TIA Aspirin Trial) prevention of vascular events, and 1 (Dutch TIA Aspirin Trial) assessed different doses of aspirin. Follow-up for colorectal cancer incidence and mortality was extended in each trial through searches of national cancer and death registries. Individual patient data were pooled from the 4 trials comparing aspirin with control (n =>14>033, mean age 61 y at randomization, 88% men). Main results Over a median follow-up of 18.3 years, aspirin, 75 to 1200 mg/d, reduced risk for colorectal cancer and colon cancer and related mortality but not rectal cancer or related mortality (Table). Aspirin reduced risk for proximal colon cancer and related mortality but not distal colon cancer and related mortality (Table). Benefit of aspirin increased with duration of treatment; aspirin for >5 years also reduced risk for rectal cancer and related mortality (Table). Conclusions Aspirin reduces risk for colon cancer and related mortality, particularly proximal colon cancer at 20 years. Effects are more pronounced when aspirin is taken for >5 years.


Related Articles

  • Effect of Including Cancer Mortality on the Cost-Effectiveness of Aspirin for Primary Prevention in Men. Pignone, Michael; Earnshaw, Stephanie; McDade, Cheryl; Pletcher, Mark // JGIM: Journal of General Internal Medicine;Nov2013, Vol. 28 Issue 11, p1483 

    BACKGROUND: Recent data suggest that aspirin may be effective for reducing cancer mortality. OBJECTIVE: To examine whether including a cancer mortality-reducing effect influences which men would benefit from aspirin for primary prevention. DESIGN: We modified our existing Markov model that...

  • A few aspirins a week. Rodgers, Katie // Drug Topics;10/23/95, Vol. 139 Issue 20, p38 

    Reports on the findings of Harvard researchers indicating that aspirin may reduce the risk of colon cancer. Reduction in the risk of colorectal cancer after 20 years of aspirin use.

  • Does long term aspirin prevent cancer? Moayyedi, Paul; Jankowski, Janusz A. // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;1/1/2011, Vol. 342 Issue 7787, p5 

    The authors discuss a meta-analysis of randomized controlled trials (RCTs) on the use of aspirin to reduce the risk of non-fatal myocardial infarction, by Rothwell and colleagues, published in the 2010 issue of "Lancet." The meta-analysis found that cancer patients who took aspirin for almost...

  • The Use of Aspirin for Primary Prevention of Colorectal Cancer: A Systematic Review Prepared for the U.S. Preventive Services Task Force. DubĂ©, Catherine; Rostom, Alaa; Lewin, Gabriela; Tsertsvadze, Alexander; Barrowman, Nicholas; Code, Catherine; Sampson, Margaret; Moher, David // Annals of Internal Medicine;3/6/2007, Vol. 146 Issue 5, p365 

    Background: Aspirin for prevention of colorectal cancer is controversial. Purpose: To examine the benefits and harms of aspirin chemoprevention. Data Sources: MEDLINE, 1966 to December 2006; EMBASE, 1980 to April 2005; CENTRAL, Cochrane Collaboration's registry of clinical trials; Cochrane...

  • Regular aspirin use and lung cancer risk. Moysich, Kirsten B.; Menezes, Ravi J.; Ronsani, Adrienne; Swede, Helen; Reid, Mary E.; Cummings, K. Michael; Falkner, Karen L.; Loewen, Gregory M.; Bepler, Gerold // BMC Cancer;2002, Vol. 2, p31 

    Background: Although a large number of epidemiological studies have examined the role of aspirin in the chemoprevention of colon cancer and other solid tumors, there is a limited body of research focusing on the association between aspirin and lung cancer risk. Methods: We conducted a...

  • Review: Daily aspirin reduces long-term risk for death due to some types of cancer. Singh, Sonal // ACP Journal Club;3/20/2011, Vol. 154 Issue 3, p1 

    Question Does daily use of aspirin reduce risk for cancer mortality? Review scope Included studies compared aspirin (any dose) with no aspirin and had a mean or median scheduled treatment duration >4 years. Trials could include other antiplatelet or antithrombotic agents if they were used in the...

  • Primary prevention of colorectal cancer with low-dose aspirin in combination with endoscopy: a cost-effectiveness analysis. Hassan, Cesare; Rex, Douglas K.; Cooper, Gregory S.; Zullo, Angelo; Launois, Robert; Benamouzig, Robert // Gut;Aug2012, Vol. 61 Issue 8, p1172 

    Objective Low-dose aspirin reduces colorectal cancer (CRC) incidence and mortality. Recently, the aspirin effect has been shown to occur primarily in the proximal colon. Colonoscopy has been either less effective or ineffective in the proximal compared to the distal colon. The authors assessed...

  • Aspirin reduces risk of colorectal cancer incidence, mortality.  // Formulary;Dec2010, Vol. 45 Issue 11, p341 

    The article discusses research showing that aspirin reduces the risk of colorectal cancer incidence and mortality. The research team conducted an independent patient data meta-analysis, following 14,000 patients for approximately 20 years of follow-up as part of five pooled randomized trials....

  • Low dose aspirin reduced long-term incidence and mortality from colorectal cancer.  // Australian Journal of Pharmacy;Feb2011, Vol. 92 Issue 1089, p70 

    The article presents a case study on the impact of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumor. It notes the establishment of the effect of aspirin on risk of colorectal cancer over 20 years during and after the trials...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics