Nilotinib, dasatinib or imatinib in CML: no clear winner

Cooper, Nick
June 2012
PharmacoEconomics & Outcomes News;6/23/2012, Issue 656, p7
Chronic myeloid leukaemia (CML) is characterised by three distinct phases: chronic phase (CP), accelerated phase (AP) and blast crisis (BC). CML is now largely treated with tyrosine kinase inhibitors (TKIs), such as the first- generation imatinib [Glivec] and the newer second-generation dasatinib [Sprycel] and nilotinib [Tasigna], which have led to dramatically improved survival rates since their introduction in the last decade. However, costs also play a part in treatment decisions. A number of studies presented at the 17th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) [Washington, DC, USA; June 2012] evaluated the costs and outcomes associated with the use of the three drugs across a range of settings.


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