Serum Visfatin Levels, Adiposity and Glucose Metabolism in Obese Adolescents

Taşkesen, Derya; Kirel, Birgül; Us, Tercan
June 2012
Journal of Clinical Research in Pediatric Endocrinology;Jun2012, Vol. 4 Issue 2, p76
Academic Journal
Objective: Visfatin, an adipokine, has insulin-mimetic effects. The main determinants of both the production and the physiologic role of visfatin are still unclear. The aim of this study is to determine the relation of serum visfatin to adiposity and glucose metabolism. Methods: 40 pubertal adolescents (20 females, 20 males; age range: 9-17 years) with exogenous obesity and 20 age- and sex-matched healthy adolescents (10 females, 10 males) were enrolled in the study. Oral glucose tolerance test (OGTT) was performed in the obese group. Serum glucose, insulin and visfatin levels were analyzed in the fasting state in the controls and at 0, 60 and 120 minutes during the OGTT in the obese group. Results: The obese group had higher serum visfatin levels than the control group [11.6 (3.3-26) ng/mL vs. 7.5 (3.3-10.5) ng/mL, p<0.001]. Visfatin levels were correlated positively with body mass index, waist/hip ratio, insulin, and homeostasis model assessment for insulin resistance and negatively with glucose/insulin ratio in the combined group (obese subjects plus controls). Visfatin levels were essentially similar in obese subjects with and without insulin resistance (p>0.05). Serum visfatin levels did not change at 60 and 120 minutes of the OGTT compared to the baseline levels (p>0.05). Conclusions:Serum visfatin levels are elevated in obese adolescents and do not change with acute changes in glucose metabolism. Visfatin levels are related with adiposity and glucose metabolism parameters. However, the role and contribution of adiposity and glucose metabolism to the circulating visfatin levels in obese patients remain to be explored.


Related Articles

  • Vaspin inhibits kallikrein 7 by serpin mechanism. Heiker, John; Klöting, Nora; Kovacs, Peter; Kuettner, E.; Sträter, Norbert; Schultz, Stephan; Kern, Matthias; Stumvoll, Michael; Blüher, Matthias; Beck-Sickinger, Annette // Cellular & Molecular Life Sciences;Jul2013, Vol. 70 Issue 14, p2569 

    The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin; serpinA12) and its mode of action are unknown. Here, we provide the vaspin crystal structure and identify human kallikrein 7 (hK7) as a first protease target of vaspin inhibited by classical serpin mechanism...

  • Adipokines and central control in adenosine A1 receptor dependent glucose metabolism. Faulhaber-Walter, Robert // Adipocyte;Apr-Jun2012, Vol. 1 Issue 2, p108 

    Adenosine A1 receptor-deficient mice develop a phenotype of insulin resistance and grow fat. Participating pathophysiological pathways are not understood in detail yet, as discussed in our recent manuscript. This commentary further explores possible pathophysiological mechanisms with emphasis on...

  • Biochemical evidence on the potential role of organophosphates in hepatic glucose metabolism toward insulin resistance through inflammatory signaling and free radical pathways. Mostafalou, Sara; Eghbal, Mohammad Ali; Nili-Ahmadabadi, Amir; Baeeri, Maryam; Abdollahi, Mohammad // Toxicology & Industrial Health;Oct2012, Vol. 28 Issue 9, p840 

    Several studies show that organophosphate pesticides exert several effects on glucose homeostasis. The current study investigates the influence of subchronic exposure to malathion (MT) on hepatic gluconeogenesis in relation to acetyl cholinesterase (AChE) inhibition, oxidative stress and...

  • Relationships Between Osteocalcin, Glucose Metabolism, and Adiponectin in Obese Children: Is there Crosstalk Between Bone Tissue and Glucose Metabolism? Abseyi, Nilay; Şıklar, Zeynep; Berberoğlu, Merih; Hacıhamdioğlu, Bülent; Savaş Erdeve, Şenay; Öçal, Gönül // Journal of Clinical Research in Pediatric Endocrinology;Dec2012, Vol. 4 Issue 4, p182 

    Objective: Recently, scientific interest has focused on the association between osteocalcin, which originates from the skeletal system, and glucose metabolism. Although the association between lipid metabolism, adiponectin, and metabolic syndrome is well known, that between obesity, insulin...

  • Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice. Pang, Jingbo; Rhodes, Davina H.; Pini, Maria; Akasheh, Rand T.; Castellanos, Karla J.; Cabay, Robert J.; Cooper, Dianne; Perretti, Mauro; Fantuzzi, Giamila // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Obesity and type 2 diabetes are associated with increased production of Galectin-3 (Gal-3), a protein that modulates inflammation and clearance of glucose adducts. We used Lean and Diet-induced Obese (DIO) WT and Gal-3 KO mice to investigate the role of Gal-3 in modulation of adiposity, glucose...

  • Metabolic disease: Obesity-associated mutations. Pola, Carolina // Nature Medicine;Dec2013, Vol. 19 Issue 12, p1582 

    The article reports the effect of kinase suppressor of Ras 2 (KSR2) in maintaining the homeostasis and glucose tolerance associated with obesity and impaired glucose metabolism in humans.

  • Approach to assessing determinants of glucose homeostasis in the conscious mouse. Hughey, Curtis; Wasserman, David; Lee-Young, Robert; Lantier, Louise // Mammalian Genome;Oct2014, Vol. 25 Issue 9/10, p522 

    Obesity and type 2 diabetes lessen the quality of life of those afflicted and place considerable burden on the healthcare system. Furthermore, the detrimental impact of these pathologies is expected to persist or even worsen. Diabetes is characterized by impaired insulin action and glucose...

  • Long-term exposure to nonylphenol affects insulin signaling in the liver of adult male rats. Jubendradass, R; D’Cruz, SC; Mathur, PP // Human & Experimental Toxicology;Sep2012, Vol. 31 Issue 9, p868 

    In the present study, we sought to investigate the long-term effects of nonylphenol (NP) on insulin signaling and glucose metabolism in liver. Furthermore, reactive oxygen species (ROS) in liver was evaluated as it is known to induce insulin resistance. Rats were administered NP by oral gavage...

  • Predictors and prevention of diabetic cardiomyopathy. Chavali, Vishalakshi; Tyagi, Suresh C.; Mishra, Paras K. // Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy;Apr2013, Vol. 6, p151 

    Despite our cognizance that diabetes can enhance the chances of heart failure, causes multiorgan failure,and contributes to morbidity and mortality, it is rapidly increasing menace worldwide. Less attention has been paid to alert prediabetics through determining the comprehensive predictors of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics