Anthropometric Measures and Risk of Ovarian Cancer Among BRCA1 and BRCA2 Mutation Carriers

McGee, Jacob; Kotsopoulos, Joanne; Lubinski, Jan; Lynch, Henry T.; Rosen, Barry; Tung, Nadine; Kim-Sing, Charmaine; Karlan, Beth; Foulkes, William D.; Ainsworth, Peter; Ghadirian, Parviz; Senter, Leigha; Eisen, Andrea; Sun, Ping; Narod, Steven A.
June 2012
Obesity (19307381);Jun2012, Vol. 20 Issue 6, p1288
Academic Journal
Studies conducted among women in the general population suggest that various anthropometric measures, including height and weight, may be associated with the risk of developing ovarian cancer. Whether such an association exists among women who carry a BRCA1 or BRCA2 mutation has not been evaluated. Thus, we investigated the association between height, weight, changes in body weight, and BMI, and the risk of developing ovarian cancer among 938 women carrying a BRCA1 or BRCA2 mutation. A matched case-control study was conducted in 469 pairs of women carrying a deleterious mutation in either BRCA1 (n = 403 pairs) or BRCA2 (n = 66 pairs). Information about height and weight at ages 18, 30, and 40 was collected from a questionnaire routinely administered to women during the course of genetic counseling. Conditional logistic regression was used to estimate the association between these body size measures and the risk of ovarian cancer. Height, weight, and BMI were not associated with the risk of ovarian cancer (P-trend ≥0.15). Also, there was no association between changes in body weight between ages 18-30, or ages 30-40, or ages 18-40 and the risk of ovarian cancer (P-trend ≥0.28). The results from this study suggest that height, weight, or weight gain do not influence the risk of ovarian cancer among carriers of a BRCA1 or BRCA2 mutation.


Related Articles

  • BMI at 4 years of age is associated with previous and current protein intake and with paternal BMI. Öhlund, I.; Hernell, O.; Hörnell, A.; Stenlund, H.; Lind, T. // European Journal of Clinical Nutrition;Feb2010, Vol. 64 Issue 2, p138 

    Objectives:To evaluate possible associations between body mass index (BMI) at 4 years of age, current and previous dietary intakes and parental BMI.Methods:A follow-up of dietary intake and anthropometry in 127 4-year-old children corresponding to 54% of children who completed an initial...

  • Asociación entre el índice de masa corporal materno, la ganancia de peso gestacional y el peso al nacer; estudio prospectivo en un departamento de salud. Vila-Candel, Rafael; Soriano-Vidal, F. J.; Navarro-Illana, R.; Murillo, M.; Martin-Moreno, J. M. // Nutricion Hospitalaria;abr2015, Vol. 31 Issue 4, p1551 

    Objectives: To ascertain the relationship between maternal weight gain and birth weight, in every pre-gestational body mass index (BMI) category. Material and Methods: A two-stage sampling observational and descriptive study was carried out in the health department of La Ribera (Valencia,...

  • Weight loss maintenance: Predictors of successful weight loss maintenance: a qualitative comparative analysis.  // British Dental Journal;11/7/2014, Vol. 217 Issue 9, p525 

    Weight gain during the first few months following weight loss, would indicate future relapse.

  • Work stress, weight gain and weight loss: evidence for bidirectional effects of job strain on body mass index in the Whitehall II study. Kivimäki, M.; Head, J.; Ferrie, J. E.; Shipley, M. J.; Brunner, E.; Vahtera, J.; Marmot, M. G.; Kivimäki, M // International Journal of Obesity;Jun2006, Vol. 30 Issue 6, p982 

    Objective: Previous research has focused on overall associations between work stress and body mass index (BMI) ignoring the possibility that stress may cause some people to eat less and lose weight and others to eat more. Using longitudinal data, we studied whether work stress...

  • Mechanisms underlying center of pressure displacements in obese subjects during quiet stance. Menegoni, Francesco; Tacchini, Elena; Bigoni, Matteo; Vismara, Luca; Priano, Lorenzo; Galli, Manuela; Capodaglio, Paolo // Journal of NeuroEngineering & Rehabilitation (JNER);2011, Vol. 8 Issue 1, p20 

    Objective: the aim of this study was to assess whether reduced balance capacity in obese subjects is secondary to altered sensory information. Design: cross sectional study. Subjects: 44 obese (BMI = 40.6 ± 4.6 kg/m² , age = 34.2 ± 10.8 years, body weight: 114,0 ± 16,0 Kg, body...

  • Second Trimester Insulin Resistance, Early Pregnancy Body Mass Index and Gestational Weight Gain. Stuebe, Alison M.; McElrath, Thomas F.; Thadhani, Ravi; Ecker, Jeffrey L. // Maternal & Child Health Journal;Mar2010, Vol. 14 Issue 2, p254 

    Objectives Because prior work suggests an association between high insulin concentrations in early pregnancy and excess gestational weight gain, we examined such associations in a prospective cohort. Methods Multivariate regression analysis of early pregnancy insulin homeostasis and gestational...

  • Antropologic Factors in Prediction of Ovary Cancer. Vraneš, Hrvojka Soljačić; Klarić, Petar; Vraneš, Zoran; Grubišić, Goran; Gorajščan, Vesna // Collegium Antropologicum;Jun2007, Vol. 31 Issue 2, p541 

    The aim of the study was to determine a combination of anthropometric variables that would enable better differentiation between benign and malignant ovarian masses. Prospective study has been performed in a two year period in which 208 women with ovarian lesions were analyzed and correlated...

  • The effects of changing exercise levels on weight and age-related weight gain. Williams, P. T.; Wood, P. D. // International Journal of Obesity;Mar2006, Vol. 30 Issue 3, p543 

    Objective:To determine prospectively whether physical activity can prevent age-related weight gain and whether changing levels of activity affect body weight.Design/subjects:The study consisted of 8080 male and 4871 female runners who completed two questionnaires an average (±standard...

  • The Association of Restrained Eating With Weight Change Over Time in a Community-Based Sample of Twins. Schur, Ellen A.; Heckbert, Susan R.; Goldberg, Jack H. // Obesity (19307381);Jun2010, Vol. 18 Issue 6, p1146 

    We investigated the association of restrained eating with BMI and weight gain while controlling for the influence of genes and shared environment. Participants were 1,587 twins enrolled in the University of Washington Twin Registry (UWTR). Restrained eating was assessed by the Herman and Polivy...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics