Metabolism: In need of a NADPH rush?

McCarthy, Nicola
June 2012
Nature Reviews Cancer;Jun2012, Vol. 12 Issue 6, p374
Academic Journal
The article discusses research on the need for the conservation of NADPH to allow redox reactions, which references the study "NADPH homeostasis to promote tumour cell survival during energy stress," by S. M. Jeon and colleagues in the May 9, 2012 issue of "Nature."


Related Articles

  • Bacterial redox sensors. Green, Jeffrey; Paget, Mark S. // Nature Reviews Microbiology;Dec2004, Vol. 2 Issue 12, p954 

    Redox reactions pervade living cells. They are central to both anabolic and catabolic metabolism. The ability to maintain redox balance is therefore vital to all organisms. Various regulatory sensors continually monitor the redox state of the internal and external environments and control the...

  • Peroxiredoxins as multifunctional enzymes. Sharapov, M.; Ravin, V.; Novoselov, V. // Molecular Biology;Jul2014, Vol. 48 Issue 4, p520 

    Peroxiredoxins are an evolutionary ancient widespread group of selenium-independent peroxidases. Peroxiredoxins protect cells from various peroxides, play an important role in maintaining redox homeostasis, and are additionally involved in transmitting extracellular and intracellular signals....

  • Thiol Signalling Network with an Eye to Diabetes. Matteucci, Elena; Giampietro, Ottavio // Molecules;Dec2010, Vol. 15 Issue 12, p8890 

    Redox regulatory system controls normal cellular functions. Controlled changes in redox couples potential serve as components for signal transduction, similarly to the phosphorylation cascade. Cellular redox biology requires both compartimentalisation and communication of redox systems: the...

  • Mitochondria and redox homoeostasis as chemotherapeutic targets. Briehl, Margaret M.; Tome, Margaret E.; Wilkinson, Sarah T.; Jaramillo, Melba C.; Lee, Kristy // Biochemical Society Transactions;Aug2014, Vol. 42 Issue 4, p939 

    Characteristics of cancer cells include a more oxidized redox environment, metabolic reprogramming and apoptosis resistance. Our studies with a lymphoma model have explored connections between the cellular redox environment and cancer cell phenotypes. Alterations seen in lymphoma cells made...

  • Chloroplastic thioredoxin-f and thioredoxin-m1/4 play important roles in brassinosteroids-induced changes in CO2 assimilation and cellular redox homeostasis in tomato. Cheng, Fei; Zhou, Yan-Hong; Xia, Xiao-Jian; Shi, Kai; Zhou, Jie; Yu, Jing-Quan // Journal of Experimental Botany;Aug2014, Vol. 65 Issue 15, p1 

    Virus-induced gene silencing (VIGS) was used in this study to characterize the role of thioredoxin-f and thioredoxin-m1/4 in brassinosteroid-induced changes in CO2 assimilation and cellular redox homeostasis in tomato.Chloroplast thioredoxins (TRXs) and glutathione function as redox messengers...

  • Redox status in acute ischemic stroke: correlation with clinical outcome. Paspalj, Dalibor; Nikic, Petar; Savic, Milan; Djuric, Dragan; Simanic, Igor; Zivkovic, Vladimir; Srejovic, Ivan; Jakovljevic, Vladimir; Jeremic, Nevena // Molecular & Cellular Biochemistry;Aug2015, Vol. 406 Issue 1/2, p75 

    Connection between oxidative stress and clinical outcome in acute ischemic stroke (AIS) has been poorly investigated. This study was aimed to assess redox state (through measurement of oxidative stress markers) of patients with acute ischemic stroke during different stages of follow-up period,...

  • Analytical Approaches for the Quantitation of Redox-active Pyridine Dinucleotides in Biological Matrices. Somogyi, Anna; Horvai, George; Csala, Miklós; Tóth, Blanka // Periodica Polytechnica: Chemical Engineering;2016, Vol. 60 Issue 4, p218 

    Some of the main electron carriers in the metabolism are mono- or dinucleotides and they play crucial roles in maintaining a balanced redox homeostasis of cells, and in coupling many anabolic and catabolic reactions. Altered cellular redox status can be an indicator of various metabolic...

  • Oxidative Stress Mechanisms and Potential Therapeutic Modalities in Alzheimer Disease. Cash, Adam D.; Smith, Mark A.; Perry, George // Medicinal Chemistry Reviews - Online;Jan2004, Vol. 1 Issue 1, p19 

    Alzheimer disease is characterized by oxidative damage to every class of biological macromolecule. Disruptions in iron and copper homeostasis are implicated as having key roles in neurodegenerative disease pathogenesis. Metal homeostasis as it pertains to alterations in brain function and its...

  • Structural and Functional Diversity of Glutaredoxins in Yeast. Herrero, Enrique; Bell�, Gemma; Casas, Celia // Current Protein & Peptide Science;Dec2010, Vol. 11 Issue 8, p659 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics