TITLE

Extending the Aerolysin Family: From Bacteria to Vertebrates

AUTHOR(S)
Szczesny, Pawel; Iacovache, Ioan; Muszewska, Anna; Ginalski, Krzysztof; van der Goot, F. Gisou; Grynberg, Marcin
PUB. DATE
June 2011
SOURCE
PLoS ONE;2011, Vol. 6 Issue 6, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A number of bacterial virulence factors have been observed to adopt structures similar to that of aerolysin, the principal toxin of Aeromonas species. However, a comprehensive description of architecture and structure of the aerolysin-like superfamily has not been determined. In this study, we define a more compact aerolysin-like domain - or aerolysin fold - and show that this domain is far more widely spread than anticipated since it can be found throughout kingdoms. The aerolysin-fold could be found in very diverse domain and functional contexts, although a toxic function could often be assigned. Due to this diversity, the borders of the superfamily could not be set on a sequence level. As a border-defining member, we therefore chose pXO2-60 - a protein from the pathogenic pXO2 plasmid of Bacillus anthracis. This fascinating protein, which harbors a unique ubiquitin-like fold domain at the C-terminus of the aerolysin-domain, nicely illustrates the diversity of the superfamily. Its putative role in the virulence of B. anthracis and its three dimensional model are discussed
ACCESSION #
74274553

 

Related Articles

  • Host Immune Responses to Aeromonas Virulence Factors. Galindo, Cristi L.; Sha, Jian; Fadl, Amin A.; Pillai, Lakshmi L.; Chopra, Ashok K. // Current Immunology Reviews;2006, Vol. 2 Issue 1, p13 

    Aeromonas species are emerging human pathogens, which produce an array of virulence factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria can be found in food and water and grow well and produce toxins at refrigeration temperatures, which greatly increase...

  • Putative Virulence Factors of the Aeromonas spp. Isolated from Food and Environment in Abu Dhabi, United Arab Emirates. Bashir Awan, Mohammad; Maqbool Ahmed, M.; Bari, Abdul; Krovacek, Karel // Journal of Food Protection;Jul2006, Vol. 69 Issue 7, p1913 

    Thirty randomly selected Aeromonas isolates from food and the environment in Abu Dhabi, United Arab Emirates, were characterized for putative virulence determinants, such as production of cytotoxin, cytotonic toxin, and hemolysin and their capacity to adhere to and invade Henle 407 cells in...

  • Molecular detection of the Aeromonas virulence aerolysin gene in retail meats from different animal sources in Egypt. Osman, Kamelia; Aly, Magdy; Kheader, Afaf; Mabrok, Khaled // World Journal of Microbiology & Biotechnology;May2012, Vol. 28 Issue 5, p1863 

    Meat commonly contain the same Aeromonas spp. which occur in human diarrhoeal and non-diarrhoeal faecal samples. Motile Aeromonas were isolated from 5.6% of total 302 samples. The distribution of the isolates were 5.9 and 5.2% in fresh and frozen samples, respectively. Of the 302 samples taken...

  • A multiplex PCR for detection of haemolytic aeromonas hydrophila from vegetable sources in Karnataka, India. Venkataiah, Puttalingamma; Poojary, Niveditha Sundar; Harshvardhan, Batra // Recent Research in Science & Technology;Mar2013, Vol. 5 Issue 3, p19 

    Aeromonas hydrophila and other aeromonads are ubiquitous organisms commonly found in majority of food matrices intended for human consumption. They cause diarrhea, septicemia and extra-intestinal infections in normal and immunocompromised patients. The aim of the present study, to develop a...

  • The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence. Balachandran, Priya; Dragone, Leonard; Garrity-Ryan, Lynne; Lemus, Armando; Weiss, Arthur; Engel, Joanne // Journal of Clinical Investigation;Feb2007, Vol. 117 Issue 2, p419 

    Pseudomonas aeruginosa, an important cause of opportunistic infections in humans, delivers bacterial cytotoxins by type III secretion directly into the host cell cytoplasm, resulting in disruption of host cell signaling and host innate immunity. However, little is known about the fate of the...

  • Distribution of 13 virulence genes among clinical and environmental Aeromonas spp. in Western Australia. Aravena-Román, M.; Inglis, T.; Riley, T.; Chang, B. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2014, Vol. 33 Issue 11, p1889 

    We evaluated the pathogenic potential of 98 clinical and 31 environmental Aeromonas isolates by detecting the presence of 13 virulence genes using a polymerase chain reaction (PCR)-based method. The majority (96 %) of the strains contained at least one of the virulence genes. The overall...

  • Virulence Diversity among Bacteremic Aeromonas Isolates: Ex Vivo, Animal, and Clinical Evidences. Chen, Po-Lin; Wu, Chi-Jung; Tsai, Pei-Jane; Tang, Hung-Jen; Chuang, Yin-Ching; Lee, Nan-Yao; Lee, Ching-Chi; Li, Chia-Wen; Li, Ming-Chi; Chen, Chi-Chung; Tsai, Hung-Wen; Ou, Chun-Chun; Chen, Chang-Shi; Ko, Wen-Chien // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Background: The objective of this study was to compare virulence among different Aeromonas species causing bloodstream infections. Methodology/Principal Findings: Nine of four species of Aeromonas blood isolates, including A. dhakensis, A. hydrophila, A. veronii and A. caviae were randomly...

  • Melanization and Pathogenicity in the Insect, Tenebrio molitor, and the Crustacean, Pacifastacus leniusculus, by Aeromonas hydrophila AH-3. Noonin, Chadanat; Jiravanichpaisal, Pikul; Söderhäll, Irene; Merino, Susana; Tomás, Juan M.; Söderhäll, Kenneth // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    Aeromonas hydrophila is the most common Aeromonas species causing infections in human and other animals such as amphibians, reptiles, fish and crustaceans. Pathogenesis of Aeromonas species have been reported to be associated with virulence factors such as lipopolysaccharides (LPS), bacterial...

  • Cooperation and competition in pathogenic bacteria. Griffin, Ashldgh S.; West, Stuarf A.; Buckling, Angus // Nature;8/26/2004, Vol. 430 Issue 7003, p1024 

    Explaining altruistic cooperation is one of the greatest challenges for evolutionary biology. One solution to this problem is if costly cooperative behaviours are directed towards relatives. This idea of kin selection has been hugely influential and applied widely from microorganisms to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics