The protective role of vanillic acid against acetaminophen induced hepatotoxicity in rats

Raja, Boobalan; Mol, Sathiyan Deepa
July 2010
Journal of Pharmacy Research;Jul2010, Vol. 3 Issue 7, p1480
Academic Journal
The potential protective role of vanillic acid one of the major phenolic derivatives from edible plants and fruits was evaluated against the acetaminophen (APAP) induced hepatotoxicity in rats. Toxicity was induced in adult male albino rats, weighing 140-160 g, by an intraperitoneal injection of APAP (750 mg/kg body weight) for 7 days. Rats were treated with vanillic acid (100 mg/kg body weight) by oral administration. We assessed the activity of hepatic markers (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and bilirubin) and lipid peroxidative markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides).The toxic effect of APAP was assessed by means of determining the activity and levels of antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), vitamin C, vitamin E and reduced glutathione (GSH) levels). Vanillic acid at an oral dose of 100 mg/kg showed a significant hepatoprotective effect by reading levels of liver marker enzymes and also bilirubin levels in serum. Regarding the antioxidant activity, vanillic acid increasing the enzymatic and non-enzymatic antioxidants and reducing TBARS and hydroperoxide levels. Histopathological findings of vanillic acid against the acetaminophen (APAP) induced hepatotoxicity rats liver confirmed the biochemical findings of this study. These results provide evidence that inhibition of TBARS and hydroperoxide over production and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of vanillic acid against APAP-induced hepatotoxicity in rats.


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