TITLE

Low-Molecular-Weight Methylcellulose-Based Thermo-reversible Gel/Pluronic Micelle Combination System for Local and Sustained Docetaxel Delivery

AUTHOR(S)
Kim, Jang; Won, Young-Wook; Lim, Kwang; Kim, Yong-Hee
PUB. DATE
February 2012
SOURCE
Pharmaceutical Research;Feb2012, Vol. 29 Issue 2, p525
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). Methods: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. Results: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40°C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. Conclusions: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.
ACCESSION #
70530502

 

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