TITLE

Mendel's Genes: Toward a Full Molecular Characterization

AUTHOR(S)
Reid, James B.; Ross, John J.
PUB. DATE
September 2011
SOURCE
Genetics;Sep2011, Vol. 189 Issue 1, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The discipline of classical genetics is founded on the hereditary behavior of the seven genes studied by Gregor Mendel. The advent of molecular techniques has unveiled much about the identity of these genes. To date, four genes have been sequenced: A (flower color), LE (stem length), I (cotyledon color), and R (seed shape). Two of the other three genes, GP (pod color) and FA (fasciation), are amenable to candidate gene approaches on the basis of their function, linkage relationships, and synteny between the pea and Medicago genomes. However, even the gene (locus) identity is not known for certain for the seventh character, the pod form, although it is probably V. While the nature of the mutations used by Mendel cannot be determined with certainty, on the basis of the varieties available in Europe in the 1850s, we can speculate on their nature. It turns out that these mutations are attributable to a range of causes--from simple base substitutions and changes to splice sites to the insertion of a transposon-like element. These findings provide a fascinating connection between Mendelian genetics and molecular biology that can be used very effectively in teaching new generations of geneticists. Mendel's characters also provide novel insights into the nature of the genes responsible for characteristics of agronomic and consumer importance.
ACCESSION #
66756325

 

Related Articles

  • Imprinted and More Equal. Jirtle, Randy L.; Weidman, Jennifer R. // American Scientist;Mar/Apr2007, Vol. 95 Issue 2, p143 

    The article discusses the phenomenon of imprinting, in which swaths of deoxyribonucleic acid on one of a pair of chromosomes are silenced. Gregor Mendel, the 19th-century monk who helped define genetics, never encountered imprinted genes during his studies. Mendel was the first to explain the...

  • The Genetics of Obesity. Hunter, William // Destined Body: How Genetics & Environment Shape Us;2005, p36 

    This article discusses the genetic causes of obesity. Obesity is a serious condition that rarely results from simply making bad eating and exercise choices. Obese individuals almost always have some genetic predisposition to the disease, and science is uncovering the factors that come into play...

  • Mendel's Law.  // Exploring the Native Plant World: A Life Science Curriculum 5th-;2004, p6 

    This article discusses the basic principles of genetics as conceptualized by scientist Gregor Mendel. Mendel is a famous scientist that concluded that hereditary factors usually come in two packages containing genes. In this regard, the author developed several scientific principles which are...

  • REASEARCH.  // Beekeepers Quarterly;Sep2011, Issue 105, p22 

    The article presents the author's insights on the genetics of insects, particularly honey bees The author mentions that studying genetic control is a challenging task and that some of its work was done in insects suchlike honey bees. He states that honey bees are terrific for analyzing the...

  • HAPPY BIRTHDAY DNA. Ireland, Tom // Biologist;Apr/May2013, Vol. 60 Issue 2, p22 

    The article examines how the human genome project and the discovery of the structure of DNA have contributed to modern genetics, highlighting the anniversaries of their discovery in April 2013. It provides a background of genetics which started in 1866 with Gregor Mendel's experiments on...

  • On Gene Concepts and Teaching Genetics: Episodes from Classical Genetics. Burian, Richard // Science & Education;Feb2013, Vol. 22 Issue 2, p325 

    This paper addresses the teaching of advanced high school courses or undergraduate courses for non-biology majors about genetics or history of genetics. It will probably be difficult to take the approach described here in a high school science course, although the general approach could help...

  • Genetics.  // Science...Non-Fiction;2005, p34 

    The article offers information about genetics, the branch of biology that studies heredity and variations among organisms. It discusses the contribution of Gregor Johann Mendel to the field of genetics. It defines heredity and genes and explains the concept of genotypes and phenotypes. It...

  • Limits to Causal Inference based on Mendelian Randomization: A Comparison with Randomized Controlled Trials. Nitsch, Dorothea; Molokhia, Mariam; Smeeth, Liam; DeStavola, Bianca L.; Whittaker, John C.; Leon, David A. // American Journal of Epidemiology;Mar2006, Vol. 163 Issue 5, p397 

    “Mendelian randomization” refers to the random assortment of genes transferred from parent to offspring at the time of gamete formation. This process has been compared to a randomized controlled trial of genetic variants. This could greatly aid observational epidemiology by...

  • Gregor Mendel and the Seven Genes (1). Yoshio Tateno // Interdisciplinary Bio Central;2013, Issue 5, p1 

    This essay describes G. Mendel's life and his law of inheritance. He was born in a poor family in 1822 in a hamlet in Czechs. At that time the Habsburg Empire dominated over the East Europe in which Vienna was the capital. Vienna had thus been the center of culture and learning, and attracted...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics