- Under your skin. Westphal, Sylvia Pagán // New Scientist;3/16/2002, Vol. 173 Issue 2334, p12
Reports the plasticity of adult stem cells found in the epidermal layer of the skin. Isolation and sorting of cells based on size and surface proteins; Concern over the occurrence of abnormal cell fusion; Implications of discovery for stem cell therapy.
- Cell fusion causes confusion. Wurmser, Andrew E.; Gage, Fred H. // Nature;4/4/2002, Vol. 416 Issue 6880, p485
Focuses on the misinterpretation of cell fusion as transdifferentiation in stem cells. Effort of some biochemist to prove the misconception of transdifferentiation; Experiments conducted to test transdifferentiation in vitro; Comparison between cell fusion and transdifferentiation.
- Changing potency by spontaneous fusion. Qi-Long Ying; Nichols, Jennifer; Evans, Edward P.; Smith, Austin G. // Nature;4/4/2002, Vol. 416 Issue 6880, p545
Examines on spontaneous cell fusion to cause changes on cell potency. Analysis on progenitor cells of central nervous system to give rise to non-neural derivatives; Exhibition of full pluripotent character in tetraploid hybrids; Transdetermination to cell fusion to underlie observation on the...
- Nerve stem cells produce endothelial lineages without cell fusion. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Sep2004, Vol. 9 Issue 3, p263
Focuses on a claim that nerve stem cells produce endothelial lineages without cell fusion. Significance of cell fusion; Factor regulating the transdifferentiation of human neural stem cells; Characteristic of endothelial cells.
- Biologists question adult stem-cell versatility. DeWitt, Natalie; Knight, Jonathan // Nature;3/28/2002, Vol. 416 Issue 6879, p354
Examines the embryonic stem cells to revolutionize treatments from heart disease to Parkinson's disease. Validity of results according to scientific conference on stem cells; Discussions on transdiffrentiation for medical use; Details on cell fusion.
- In the News. // American Scientist;Sep/Oct2006, Vol. 94 Issue 5, p411
The article presents an update on issues related to scientific research. Zoologists have discovered that adult meerkats teach their offsprings how to eat dangerous animals. A protein called Nanog promotes the creation of pluripotent cells from the fusion of a stem cell with a more specialized...
- Nanog: the gift of choice. Amoils, Shannon // Nature Reviews Molecular Cell Biology;Aug2006, Vol. 7 Issue 8, p555
The article discusses the role of homeodomain protein nanog in the purport in embryonic stem cells. The donation of pluripotency to somatic cells after ES-somatic cell fusion is discussed. The cause of the increased yield of pluripotent hybrid colonies is highlighted. There is an increase in the...
- Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Wurmser, Andrew E.; Nakashima, Kinichi; Summers, Robert G.; Toni, Nicolas; D'Amour, Kevin A.; Lie, Dieter C.; Gage, Fred H. // Nature;7/15/2004, Vol. 430 Issue 6997, p350
Somatic stem cells have been claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticity) that could be induced by exposing stem cells to the extracellular developmental signals of other lineages in mixed-cell cultures. Recently, this and other experimental...
- A Stem Cell Fusion Model of Carcinogenesis. Xianghui He; Tsang, Tom C.; Pipes, Brain L.; Ablin, Richard J.; Harris, David T. // Journal of Experimental Therapeutics & Oncology;2005, Vol. 5 Issue 2, p101
The origin of cancer remains enigmatic. Current models of carcinogenesis based on the gene mutation hypothesis have limitations in explaining many aspects of cancer. We put forward a new model of multistage carcinogenesis and propose that cancer development involves gene mutations and cell...