TITLE

Review: Daily aspirin reduces long-term risk for death due to some types of cancer

AUTHOR(S)
Singh, Sonal
PUB. DATE
March 2011
SOURCE
ACP Journal Club;3/20/2011, Vol. 154 Issue 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Question Does daily use of aspirin reduce risk for cancer mortality? Review scope Included studies compared aspirin (any dose) with no aspirin and had a mean or median scheduled treatment duration >4 years. Trials could include other antiplatelet or antithrombotic agents if they were used in the same way in the aspirin and no-aspirin groups. Outcome was death due to cancer. Review methods Antithrombotic Trialists Collaboration (last search 2002); MEDLINE and EMBASE/Excerpta Medica (2002 to Mar 2010); and Cochrane Database of Systematic Reviews were searched for randomized trials. Investigators were contacted for original data. 8 trials (n =>25>570) met the selection criteria; individual patient data were available for 7 (n =>23>535), and 3 (n =>12>659) included long-term posttrial follow-up data from cancer registries and national death certificates. Trials were done for prevention of vascular disease. Daily dose of aspirin ranged from 75 mg to 1200 mg. Intention-to-treat analysis was used for individual patient data. Main results Individual patient data meta-analysis showed that aspirin reduced overall risk for death due to cancer more than no aspirin (Table). In analyses by follow-up time, aspirin reduced risk for death from any cancer and from gastrointestinal (GI) cancer more than no aspirin at é>5 years and from any cancer, GI, and non-GI solid cancer at 20 years; groups did not differ at >5 years of follow-up (Table). Aspirin and no-aspirin groups did not differ for death due to hematologic cancer at any time point. Conclusion Daily use of aspirin reduces long-term risk for death due to some types of cancer.
ACCESSION #
64279620

 

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