TITLE

Clinician-Assessed Depression and HAART Adherence in HIV-Infected Individuals in Methadone Maintenance Treatment

AUTHOR(S)
Gonzalez, Jeffrey S.; Psaros, Christina; Batchelder, Abigail; Applebaum, Allison; Newville, Howard; Safren, Steven A.
PUB. DATE
August 2011
SOURCE
Annals of Behavioral Medicine;Aug2011, Vol. 42 Issue 1, p120
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The impact of measurement methods on the relationship between depression and HIV treatment adherence has not been adequately examined. Purpose: The purpose of this paper is to examine the relationship between clinician- and patient-rated depression and HIV medication adherence. Methods: The participants were 91 HIV-infected individuals in methadone maintenance. Depression was assessed via clinician ratings (Clinical Global Impression Scale and Montgomery Asberg Depression Rating Scale) and self-report (Beck Depression Inventory-Short Form). Clinicians rated substance abuse using the Clinical Global Impression Scale and a structured interview. HIV medication adherence was measured over the following 2 weeks using electronic caps. Results: Each unit increase in the Clinical Global Impression Scale was associated with 75% increased odds of nonadherence (OR = 1.75, p = 0.002, 95% CI = 1.23-2.48). Similarly, for each standard deviation Montgomery Asberg Depression Rating Scale increase, there was a 2.6-fold increased odds of nonadherence (OR = 2.60, p = 0.001, 95% CI = 1.45-4.67). Substance abuse and self-reported depression severity were not significantly related to adherence. Conclusions: Clinician-rated depression severity was a strong predictor of nonadherence. Assessment methods may influence the relationship between depression and HIV nonadherence.
ACCESSION #
62909997

 

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