Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings

Springer, Fabian; Ehehalt, Stefan; Sommer, Julia; Ballweg, Verena; Machann, Jürgen; Binder, Gerhard; Claussen, Claus D.; Schick, Fritz
April 2011
European Radiology;Apr2011, Vol. 21 Issue 4, p816
Academic Journal
Objective: To test the feasibility of fat-selective GRE imaging using a spectral-spatial excitation technique for determination of intrahepatic lipid content (IHL) in obese adolescents. Methods: Fat-selective MR imaging (1.5 T) was applied to record a single axial slice through a representative liver region within a single breath-hold. The sequence uses six equidistant slice-selective excitation pulses with binomial amplitude ratios to achieve high selectivity for lipid signals after appropriate shimming. IHL content was quantified using signal intensity of adjacent subcutaneous adipose tissue. As the gold standard for IHL quantification, single-voxel stimulated echo magnetic resonance spectroscopy (MRS) was applied. IHL was quantified using the water peak as a reference. Results: Forty-five MR examinations could be performed, and IHL content ranged from 0.7% to 19.1%. Results from MRS and fat-selective imaging correlated well with Spearman coefficients between r = 0.78 and r = 0.86. There were no relevant regional differences in IHL within the liver parenchyma ( p > 0.6359). Fat-selective imaging was able to reliably identify patients with IHL content above 5% with positive/negative likelihood ratio of 11.8 and 0.05, respectively. Conclusion: Fat-selective MR imaging provides both a reliable and a convenient method of rapidly quantifying IHL content in obese adolescents.


Related Articles

  • Single Slice vs. Volumetric MR Assessment of Visceral Adipose Tissue: Reliability and Validity Among the Overweight and Obese. Maislin, Greg; Ahmed, Murtuza M.; Gooneratne, Nalaka; Thorne-Fitzgerald, Matt; Kim, Christopher; Teff, Karen; Arnardottir, Erna S.; Benediktsdottir, Bryndis; Einarsdottir, Hildur; Juliusson, Sigurdur; Pack, Allan I.; Gislason, Thorarinn; Schwab, Richard J. // Obesity (19307381);Oct2012, Vol. 20 Issue 10, p2124 

    Visceral adipose tissue (VAT) is associated with abnormal cardiovascular and metabolic profiles. Total VAT volume of the abdominal compartment by magnetic resonance imaging (MRI) is the gold-standard measurement for VAT but is costly and time consuming. Prior studies suggest VAT area on a single...

  • Automatic segmentation of thigh magnetic resonance images. Urricelqui, Lorena; Malanda, Armando; Villanueva, Arantxa // World Academy of Science, Engineering & Technology;Oct2009, Issue 34, p979 

    Purpose: To develop a method for automatic segmentation of adipose and muscular tissue in thighs from magnetic resonance images. Materials and methods: Thirty obese women were scanned on a Siemens Impact Expert 1T resonance machine. 1500 images were finally used in the tests. The developed...

  • Inverse relation between dietary fiber intake and visceral adiposity in overweight Latino youth.  // American Journal of Clinical Nutrition;Nov2009, Vol. 90 Issue 5, p1160 

    The article presents a study which examines the link between dietary intake changes and adiposity and risk factor changes in overweight patients with type 2 diabetes. It used dual-energy X-ray absorptiometry and magnetic resonance imaging, glucose tolerance tests, and partial correlations to...

  • Magnetic resonance imaging of abdominal adiposity in a large cohort of British children. Benfield, L. L; Fox, K. R.; Peters, D. M.; Blake, H.; Rogers, I.; Grant, C.; Ness, A. // International Journal of Obesity;Jan2008, Vol. 32 Issue 1, p91 

    Objective:To describe abdominal adipose tissue distribution in a large sample of contemporary British children; to determine the influence of gender, stage of maturation and body mass index (BMI) on abdominal adipose tissue distribution; and to compare the ability of BMI and waist circumference...

  • Validity of a new automated software program for visceral adipose tissue estimation. Demerath, E. W.; Ritter, K. J.; Couch, W. A.; Rogers, N. L.; Moreno, G. M.; Choh, A.; Lee, M.; Remsberg, K.; Czerwinski, S. A.; Chumlea, W. C.; Siervogel, R. M.; Towne, B. // International Journal of Obesity;Feb2007, Vol. 31 Issue 2, p285 

    Introduction:Given the considerable time and research cost of analyzing biomedical images to quantify adipose tissue volumes, automated image analysis methods are highly desirable. Hippo Fatâ„¢ is a new software program designed to automatically quantify adipose tissue areas from magnetic...

  • Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue. Thomas, E L; Bell, J D // International Journal of Obesity & Related Metabolic Disorders;Feb2003, Vol. 27 Issue 2, p211 

    OBJECTIVE:: Single-slice magnetic resonance imaging (MRI) and computed tomography (CT) are finding increasing use as methods to estimate visceral fat content in human studies. To assess the validity of this approach, we have compared single- and multi-slice MRI methods for the measurement of...

  • Weight-loss diet alone or combined with resistance training induces different regional visceral fat changes in obese women. Idoate, F; Ibañez, J; Gorostiaga, E M; García-Unciti, M; Martínez-Labari, C; Izquierdo, M // International Journal of Obesity;May2011, Vol. 35 Issue 5, p700 

    Background:Quantification of abdominal fat and its regional distribution has become increasingly important in assessing the cardiovascular risk.Objective:To examine the effects of 16 weeks of a hypocaloric diet with a caloric restriction of 500 Kcal per day (WL) or the same dietary intervention...

  • Quantitative comparison and evaluation of software packages for assessment of abdominal adipose tissue distribution by magnetic resonance imaging. Bonekamp, S.; Ghosh, P.; Crawford, S.; Solga, S. F.; Horska, A.; Brancati, F. L.; Diehl, A. M.; Smith, S.; Clark, J. M. // International Journal of Obesity;Jan2008, Vol. 32 Issue 1, p100 

    Objective:To examine five available software packages for the assessment of abdominal adipose tissue with magnetic resonance imaging, compare their features and assess the reliability of measurement results.Design:Feature evaluation and test–retest reliability of softwares (NIHImage,...

  • Central Obesity and Liver Iron Content: A Noninvasive Assessment in General Population by Magnetic Resonance Imaging. Radmard, amir Reza; Poustchi, Hossein; Hashemi Taheri, amir Pejman; Gerami Seresht, Marjan; Mohammadinejad, Payam; Yoonessi, ali; Dadgostar, Mehrdad; Rahmanian, Mohammad Sadegh; Jafari, Elham; Zeinoddini, atefeh; Malekzadeh, Reza; Merat, Shahin // Annals of Nutrition & Metabolism;Jan2017, Vol. 69 Issue 3/4, p181 

    Background/Aim: Existing evidence points to an altered status of iron metabolism in obesity. We aimed to investigate whether central obesity is independently associated with estimated liver iron content (liverT2* value) in general population that used the noninvasive assessment method by MRI....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics