TITLE

Broad neutralizing antibody response and genetic variation in HIV-1 env genes in Koreans with primary HIV-1 infections

AUTHOR(S)
Shin, Bo; Kim, Sung; Kim, Gab
PUB. DATE
March 2011
SOURCE
Archives of Virology;Mar2011, Vol. 156 Issue 3, p465
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To determine the neutralization profiles induced by HIV-1 Korean clade B, which has a monophyletic lineage and relative limited genetic diversity, we investigated the ability of HIV variants to elicit neutralizing antibodies in the immune response to primary infection. We selected seven Korean drug-naïve subjects with an HIV-1 primary infection and did pseudovirion-based neutralization assays using env genes of Korean HIV origin. The neutralizing antibody responses to the Korean clade B showed broad reactivity to subtype B but a highly subtype-specific pattern. The lengths of the amino acid sequences and the PNGS numbers in the V1-V5 region were positively correlated with neutralization. These results imply that the genetic characteristics of HIV-1 env may affect neutralizing antibody responses in HIV-1-infected individuals. This is the first report describing the relationship between neutralizing antibody responses and HIV-1 genetic characteristics in Korean subjects. It can be useful for developing AIDS vaccines against HIV-1 subtype B strains.
ACCESSION #
58627708

 

Related Articles

  • What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? Campbell, Grant R.; Loret, Erwann P. // Retrovirology;2009, Vol. 6, p1 

    The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat is an important factor in viral pathogenesis. In addition to its function as the key trans-activator of viral transcription, Tat is also secreted by the infected cell and taken up by neighboring cells...

  • Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. Prahalad, S.; Bohnsack, J. F.; Jorde, L. B.; Whiting, A.; Clifford, B.; Dunn, D.; Weiss, R.; Moroldo, M.; Thompson, S. D.; Glass, D. N.; Bamshad, M. J. // Genes & Immunity;Sep2006, Vol. 7 Issue 6, p468 

    Juvenile rheumatoid arthritis (JRA) is mediated by Th1-immune responses. In children with JRA, synovial T cells express high levels of the Th1-chemokine receptor CC chemokine receptor 5 (CCR5), which has been implicated in susceptibility to rheumatoid arthritis. To test the hypothesis that...

  • In Shape - The Art of Mapping Conformational Epitopes. Gadermaier, Elisabeth // International Archives of Allergy & Immunology;Mar2012, Vol. 157 Issue 4, p321 

    No abstract available Copyright © 2010 S. Karger AG, Basel

  • Impaired Antibody Response to Influenza Vaccine in HIV-Infected and Uninfected Aging Women Is Associated with Immune Activation and Inflammation. Parmigiani, Anita; Alcaide, Maria L.; Freguja, Ricardo; Pallikkuth, Suresh; Frasca, Daniela; Fischl, Margaret A.; Pahwa, Savita // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Background:Aging and HIV infection are independently associated with excessive immune activation and impaired immune responses to vaccines, but their relationships have not been examined. Methods:For selecting an aging population we enrolled 28 post-menopausal women including 12 healthy...

  • Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design. Zolla-Pazner, Susan; Cardozo, Timothy // Nature Reviews Immunology;Jul2010, Vol. 10 Issue 7, p527 

    One of the main challenges of developing an HIV-1 vaccine lies in eliciting immune responses that can overcome the antigenic variability exhibited by HIV. Most HIV-1 vaccine development has focused on inducing immunity to conserved regions of the HIV-1 envelope. However, new studies of the...

  • CCL28 Induces Mucosal Homing of HIV-1-Specific IgA-Secreting Plasma Cells in Mice Immunized with HIV-1 Virus-Like Particles. Rainone, Veronica; Dubois, Gregor; Temchura, Vladimir; Überla, Klaus; Clivio, Alberto; Nebuloni, Manuela; Lauri, Eleonora; Trabattoni, Daria; Veas, Francisco; Clerici, Mario // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    Mucosae-associated epithelial chemokine (MEC or CCL28) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria. The ability of this chemokine to enhance migration of IgA-ASCs to mucosal sites was assessed in a mouse immunization model using...

  • HIV-1 Vpr: Genetic Diversity and Functional Features from the Perspective of Structure. Tungaturthi, Parithosh K.; Sawaya, Bassel E.; Ayyavoo, Velpandi; Murali, Ramachandran; Srinivasan, Alagarsamy // DNA & Cell Biology;Apr2004, Vol. 23 Issue 4, p207 

    RNA viruses are well known for the enormous genetic variation. Retroviruses share this feature with other RNA viruses, and human immunodeficiency virus type 1 (HIV-1) has been extensively investigated in this regard. Based on the DNA sequence analysis, HIV-1 has been classified into three...

  • Research Highlights. Bhatia, Jasmine; Farrell, Alison; Levinson, Randy; Schubert, Charlotte // Nature Medicine;May2006, Vol. 12 Issue 5, p513 

    The article presents an overview of several studies related to pharmacology. A study on the use of RNA interference as a therapy conducted by Tracy Zimmermann and colleagues. Another study on the gene variant which causes obesity conducted by Alan Herbert and colleagues. The study conducted by...

  • HIV/AIDS Vaccine: An Update. Nath, Anita // Indian Journal of Community Medicine;Apr2010, Vol. 35 Issue 2, p222 

    The article presents an update on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) vaccine as of April 2010. It mentions that India is facing an HIV/AIDS epidemic with 2.5 million of its population affected by such conditions. Potential HIV vaccines are discussed...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics