TITLE

Cardiac Cell Therapies: The Next Generation

AUTHOR(S)
Choi, Yeong-Hoon; Saric, Tomo; Nasseri, Boris; Hühn, Stefan; Van Linthout, Sophie; Hetzer, Roland; Tschöpe, Carsten; Stamm, Christof
PUB. DATE
February 2011
SOURCE
Cardiovascular Therapeutics;Feb2011, Vol. 29 Issue 1, p2
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Although significant advances have been made in terms of pharmacological, catheter-based, and surgical palliation, heart failure remains a fatal disease. As a curative concept, regenerative medicine aims at the restoration of the physiologic cellular composition of diseased organs. So far, clinical cardiac regeneration attempts have only been moderately successful, but a better understanding of myocardial cell homeostasis and somatic as well as embryonic stem cell biology has opened the door for the development of more potent therapeutic cardiac regeneration strategies. Accumulating evidence indicates that the postnatal mammalian heart retains a pool of tissue-specific progenitor cells and is also repopulated by cells from extracardiac sources. However, this intrinsic myocardial regeneration potential clearly needs to be augmented by either manipulation of the cell cycle of differentiated cells, activation of resident cardiac progenitor cells, and/or the transplantation of exogenous cells. This review summarizes the recent developments in cardiac regenerative medicine, many of which may find their way into the clinical setting in the foreseeable future.
ACCESSION #
57367371

 

Related Articles

  • Stem-cell-based therapy and lessons from the heart. Passier, Robert; van Laake, Linda W.; Mummery, Christine L. // Nature;5/15/2008, Vol. 453 Issue 7193, p322 

    The potential usefulness of human embryonic stem cells for therapy derives from their ability to form any cell in the body. This potential has been used to justify intensive research despite some ethical concerns. In parallel, scientists have searched for adult stem cells that can be used as an...

  • Regenerative medicine: Short cut to cell replacement. Blelloch, Robert // Nature;10/2/2008, Vol. 455 Issue 7213, p604 

    The article discusses studies by Q. Zhou and colleagues on adult cell replacement in regenerative medicine. The researchers describe an approach whereby differentiated adult cells of one type can be directly and efficiently converted into functional cells of another type within an organism and...

  • Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation. Cagavi, Esra; Bartulos, Oscar; Suh, Carol Y.; Sun, Baonan; Yue, Zhichao; Jiang, Zhengxin; Yue, Lixia; Qyang, Yibing // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    As heart failure due to myocardial infarction remains a leading cause of morbidity worldwide, cell-based cardiac regenerative therapy using cardiac progenitor cells (CPCs) could provide a potential treatment for the repair of injured myocardium. As adult CPCs may have limitations regarding...

  • Scientists produce embryonic eye from stem cells.  // Australian Life Scientist;4/7/2011, p1 

    Regenerative medicine leapt forward today as Japanese scientists were able to coax embryonic stem cells to form the precursor of an eye.

  • First Annual Worldwide Congress on Regenerative Medicine and Stem Cells (December 2—4, 2008 Foshan, People’s Republic of China). Serov, O. L.; Battulin, N. R. // Russian Journal of Developmental Biology;Mar2010, Vol. 41 Issue 2, p130 

    The article informs that the First Annual Worldwide Congress on Regenerative Medicine and Stem Cells was held during December 2-4, 2008, in Foshan, China. The congress was divided into 15 plenary sessions and two poster sessions. Applied aspects of the use of stem cells in medicine, the...

  • Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Lee, Yee-Ki; Ng, Kwong-Man; Lai, Wing-Hon; Chan, Yau-Chi; Lau, Yee-Man; Lian, Qizhou; Tse, Hung-Fat; Siu, Chung-Wah // Stem Cell Reviews & Reports;Dec2011, Vol. 7 Issue 4, p976 

    Rationale: Cardiomyocytes generated from human induced pluripotent stem cells (hiPSCs) are suggested as the most promising candidate to replenish cardiomyocyte loss in regenerative medicine. Little is known about their calcium homeostasis, the key process underlying excitation-contraction...

  • Human embryonic stem cell transplantation to repair the infarcted myocardium. Leor, Jonathan; Gerecht, Sharon; Cohen, Smadar; Miller, Liron; Holbova, Radka; Ziskind, Anna; Shachar, Michal; Feinberg, Micha S.; Guetta, Esther; Itskovitz-Eldor, Joseph // Heart;Oct2007, Vol. 93 Issue 10, p1278 

    9Objective: To test the hypothesis that human embryonic stem cells (hESCs) can be guided to form new myocardium by transplantation into the normal or infarcted heart, and to assess the influence of hESC-derived cardiomyocytes (hESCMs) on cardiac function in a rat model of myocardial infarction...

  • ACT Publishes First Report of Embryonic Stem Cell (ESC)-Derived Cells Transplanted Into Patients.  // Biomedical Market Newsletter;1/28/2012, Vol. 21, p1 

    The article informs that the report on the transplantation of human Embryonic Stem Cell (hESC)-Derived Cells has been published online in The Lancet by Advanced Cell Technology Inc. It further informs that the report discusses the safety of using hESC-derived retinal pigmentEpithelium (RPE)...

  • From embryos to embryonic stem cells: biopolitics and therapeutic potential. Cedar, S. H.; Cooke, J. A.; Luo, Z.; Patel, M. J.; Minger, S. L. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Nov2006, Vol. 13 Issue 5, p725 

    The inner cell mass of the preimplantation blastocyst, from which all the cells of the body develop, is a source of embryonic stem cells. These cells can be maintained in their undifferentiated state over long periods in culture and yet retain their pludpotency. The generation of human stem...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics