Leakproof Lab New facility for DNA work

April 1978
The article focuses on the P-4 laboratory at Fort Detrick, Maryland where hazardous genetic research can be conducted. It says that the laboratory will handle an experiment on whether recombinant deoxyribonucleic acid (DNA) research can create dangerous organisms and whether they can be handled safely in a laboratory. It mentions that Malcolm Martin and Wallace Rowe of U.S. National Institutes of Health (NIH) will combine DNA from the polyoma virus into a specially engineered strain of Escherichia coli during the first stage of the experiment. Meanwhile, it mentions that scientists change into special protective clothing before entering the laboratory while all materials used in experiments will be moved into glove boxes through an air lock.


Related Articles

  • In-vivo Effect of Probiotics on Escherichia coli O157:H7 Isolated from Salad Vegetables. Uzeh, Roseline Ekiomado; Okolo, Chinwe Amaka; Iwalokun, Bamidele Abiodun // Journal of Food Research;Nov2012, Vol. 1 Issue 4, p27 

    This study was undertaken to isolate Escherichia coli O157:H7 from salad vegetables, determine its pathogenicity and effect on the gastrointestinal tract of mice and sensitivity to probiotics; Lactobacillus lactis ATCC12315 and Lactobacillus acidophilus ATCC4356 in-vivo. Twenty seven samples...

  • Committee Splits over Downgrading of E. coil Containment. Henig, Robin Marantz // BioScience;Dec1979, Vol. 29 Issue 12, p759 

    The article presents information about the exemption of recombinant DNA experiments involving Escherichia coli (E. coli ) K-12 bacteria from the guidelines of the National Institute of Health (NIH) of the U.S. The submission of a registration document by the researcher to the local Institutional...

  • Genetic Moratorium.  // Time;7/19/1976, Vol. 108 Issue 3, p75 

    The article discusses the move of the Cambridge, Massachusetts city council to prevent the genetic research of the Harvard University and the Massachusetts Institute of Technology. The genetic research is reported to create new potentially dangerous life forms by inserting DNA segments of other...

  • Office of Biotechnology Activities; Recombinant DNA Research: Actions Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines). Tabak, Lawrence A. // Federal Register (National Archives & Records Service, Office of;2/21/2013, Vol. 78 Issue 35, p12074 

    This article presents a notice of changes to the National Institutes of Health guidelines for research involving recombinant DNA molecules.

  • The RAC: Double, Double, Toil, and Trouble? Ertl, Hildegund // Molecular Therapy;Mar2009, Vol. 17 Issue 3, p397 

    The article discusses the objective of the Recombinant DNA Advisory Committee (RAC), which is to ensure clinical trials on recombinant DNA (rDNA) research and gene transfer. The author says that the committee has developed and has been involved in revisions to the National Institutes of Health...

  • Office of Biotechnology Activities; Recombinant DNA Research: Action Under the NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines). Corrigan-Curay, Jacqueline // Federal Register (National Archives & Records Service, Office of;10/11/2011, Vol. 76 Issue 196, p62816 

    The article offers information on the move of the Office of Biotechnology Activities (OBA) to update the U.S. National Institutes of Health (NIH) Guidelines' Appendix B. It states that OBA aims to specify the risk group (RG) classification for several common attenuated strains of bacteria and...

  • Making a Safer Microbe.  // Time;4/18/1977, Vol. 109 Issue 16, p49 

    The article focuses on the initiative of geneticist Roy Curtiss III in converting the standard genetic research organism, a strain of Escherichia coli (E. coli) bacterium, in a mutant variety. He creates an E. coli with a defect in a gene that makes diaminopimelic acid (DAP) to keep the bacteria...

  • Back to Basics.  // Nature Reviews Microbiology;May2005, Vol. 3 Issue 5, p362 

    By prioritizing research on potential bioweapon agents, the NIH is diverting vital resources away from basic research on microorganisms that have an ongoing impact on public health.

  • Recombinant DNA: The Debate Goes On. Sullivan, Daniel J. // America;11/10/1979, Vol. 141 Issue 14, p280 

    The article focuses on the decision for the future of recombinant DNA research, which will be made by Dr. Donald Frederickson, director of the National Institute of Health in the U.S. His responsibilities for promoting medical research while protecting the public put him in an important but...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics