Prevalence and Clinical Significance of Epileptiform EEG Discharges in a Large Memory Clinic Cohort

Liedorp, Maarten; Stam, Cornelis J.; Van der Flier, Wiesje M.; Pijnenburg, Yolande A. L.; Scheltens, Philip
June 2010
Dementia & Geriatric Cognitive Disorders;2010, Vol. 29 Issue 5, p432
Academic Journal
Background: Although EEG is not considered as standard in memory clinics, evidence indicates that epileptiform discharges are of value in diagnosing cognitive complaints as epilepsy. Objective: To determine prevalence and significance of epileptiform discharges in a memory clinic. Methods: 1,674 consecutive patients underwent routine EEGs [mean age 66 years, diagnoses: Alzheimer disease (AD; n = 510), other dementia (n = 193), mild cognitive impairment (MCI; n = 225), subjective complaints (n = 368), and other disorders (n = 378)]. Database statistics, charts and EEG reports were reviewed. Results:Epileptiform discharges were present in 42 (3%) patients, of which 60% lacked clinical seizures. All discharges were focal and predominantly temporally localized. Epileptiform activity was not associated with a dementia diagnosis (2% in AD and 1% in other dementia vs. 2% in MCI, 2% in subjective complaints and 5% in other disorders, p = 0.07) or with lower Mini-Mental State Examination scores (p = 0.69). Two (diagnoses: AD, vascular dementia) of 20 patients with epileptiform activity without clinical seizures developed first seizures after 2 years. Conclusion: In a memory clinic cohort, epileptiform discharges are rare, nonspecific and indicate a moderate risk of first-ever seizures in demented patients. These findings should be taken into account when routinely evaluating memory clinic patients with EEG. Copyright © 2010 S. Karger AG, Basel


Related Articles

  • Long Term Effects of Piracetam on Spectral Analysis of EEG in Alzheimer's Disease and Minimal Cognitive Impairment. Degirmenci, Eylem; Şahiner, Türker; Erdogan, Çaǧdaş; Özdemir, Fatma; Gür, Selahattin; Şahiner, Melike // Klinik Psikofarmakoloji Bulteni;Jun2006, Vol. 16 Issue 2, p93 

    Objective: Influence of piracetam in post-stroke aphasia and myoclonic epilepsy has been shown with EEG spectral power analysis. Particularly piracetam is involved in restoration of alpha topography in these patients. On the other hand long term effects of piracetam in Alzheimer's disase or...

  • Electroencephalographic Rhythms in Alzheimer's Disease. Lizio, Roberta; Vecchio, Fabrizio; Frisoni, Giovanni B.; Ferri, Raffaele; Rodriguez, Guido; Babiloni, Claudio // International Journal of Alzheimer's Disease;2011, Vol. 2011, p1 

    Physiological brain aging is characterized by synapses loss and neurodegeneration that slowly lead to an age-related decline of cognition. Neural/synaptic redundancy and plastic remodelling of brain networking, also due to mental and physical training, promotes maintenance of brain activity in...

  • Associations between Patterns of EEG Abnormalities and Diagnosis in a Large Memory Clinic Cohort. Liedorp, M.; van der Flier, W. M.; Hoogervorst, E. L. J.; Scheltens, P.; Stam, C. J. // Dementia & Geriatric Cognitive Disorders;2009, Vol. 27 Issue 1, p18 

    Aim: To describe associations of abnormalities in the electroencephalogram (EEG) with the most prevalent diagnoses in a memory clinic cohort. Methods: Associations between visual EEG findings and diagnoses in 1,116 consecutive patients [382 Alzheimer’s disease (AD), 274 subjective...

  • Incidence of dementia and cognitive decline in over-75s in Cambridge: overview of cohort study. Paykel, E. S.; Huppert, F. A.; Brayne, C. // Social Psychiatry & Psychiatric Epidemiology;1998, Vol. 33 Issue 8, p387 

    This paper summarises the methods and some of the findings of a large cohort study of dementia and cognitive decline in subjects aged over 75 years in Cambridge, particularly regarding the incidence wave. From a sample of 1968 subjects previously studied in a prevalence study in 1985-1987,...

  • Memories are made of this: recent advances in understanding cognitive impairments and dementia. Banks, William A.; Morley, John E. // Journals of Gerontology Series A: Biological Sciences & Medical ;Apr2003, Vol. 58 Issue 4, p314 

    Discusses advances in understanding cognitive impairments and dementia. Information on Alzheimer's disease; Correlation between nutrition and dementia; Management of Alzheimer's disease.

  • Untitled.  // Medical Device Daily;12/2/2013, Vol. 17 Issue 231, p1 

    The article reports developments in neurology as of November 2013. Researchers at Stanford University found that decreased estrogen levels after menopause are largely unrelated to changes in cognitive abilities and mood. A study by researchers from Imperial College among people suffering from...

  • Slowing of EEG background activity in Parkinson's and Alzheimer's disease with early cognitive dysfunction. Benz, Nina; Hatz, Florian; Bousleiman, Habib; Ehrensperger, Michael M.; Gschwandtner, Ute; Hardmeier, Martin; Ruegg, Stephan; Schindler, Christian; Zimmermann, Ronan; Urs Monsch, Andreas; Fuhr, Peter // Frontiers in Aging Neuroscience;Nov2014, Vol. 6, p1 

    Background: Slowing of the electroencephalogram (EEG) is frequent in Parkinson's (PD) and Alzheimer's disease (AD) and correlates with cognitive decline. As overlap pathology plays a role in the pathogenesis of dementia, it is likely that demented patients in PD show similar physiological...

  • Experts Describe "Spectrum" of Epilepsy. Hampton, Tracy // JAMA: Journal of the American Medical Association;1/27/2010, Vol. 303 Issue 4, p313 

    The article reflects on epilepsy as a spectrum disorder. It notes that epilepsy and seizures could be a component of various conditions, like depression, autism and Alzheimer's disease. Investigators think that the mechanisms behind seizure-induced cognitive and behavioral dysfunction may...

  • Specific EEG Changes Associated with Atrophy of Hippocampus in Subjects with Mild Cognitive Impairment and Alzheimer's Disease. Moretti, D. V.; Prestia, A.; Fracassi, C.; Binetti, G.; Zanetti, O.; Frisoni, G. B. // International Journal of Alzheimer's Disease;2012, p1 

    We evaluated the association between hippocampal atrophy and increase of the EEG markers alpha3/alpha2 relative power ratio in mild cognitive impairment (MCI) and Alzheimer's disease patients. Seventy-nine subjects with MCI and 11 patients with AD underwent EEG recording and MRI scan. The MCI...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics