TITLE

Prevalence and Clinical Significance of Epileptiform EEG Discharges in a Large Memory Clinic Cohort

AUTHOR(S)
Liedorp, Maarten; Stam, Cornelis J.; Van der Flier, Wiesje M.; Pijnenburg, Yolande A. L.; Scheltens, Philip
PUB. DATE
June 2010
SOURCE
Dementia & Geriatric Cognitive Disorders;2010, Vol. 29 Issue 5, p432
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Although EEG is not considered as standard in memory clinics, evidence indicates that epileptiform discharges are of value in diagnosing cognitive complaints as epilepsy. Objective: To determine prevalence and significance of epileptiform discharges in a memory clinic. Methods: 1,674 consecutive patients underwent routine EEGs [mean age 66 years, diagnoses: Alzheimer disease (AD; n = 510), other dementia (n = 193), mild cognitive impairment (MCI; n = 225), subjective complaints (n = 368), and other disorders (n = 378)]. Database statistics, charts and EEG reports were reviewed. Results:Epileptiform discharges were present in 42 (3%) patients, of which 60% lacked clinical seizures. All discharges were focal and predominantly temporally localized. Epileptiform activity was not associated with a dementia diagnosis (2% in AD and 1% in other dementia vs. 2% in MCI, 2% in subjective complaints and 5% in other disorders, p = 0.07) or with lower Mini-Mental State Examination scores (p = 0.69). Two (diagnoses: AD, vascular dementia) of 20 patients with epileptiform activity without clinical seizures developed first seizures after 2 years. Conclusion: In a memory clinic cohort, epileptiform discharges are rare, nonspecific and indicate a moderate risk of first-ever seizures in demented patients. These findings should be taken into account when routinely evaluating memory clinic patients with EEG. Copyright © 2010 S. Karger AG, Basel
ACCESSION #
51421442

 

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