Matei, Nicoleta
June 2010
Clujul Medical;Jun2010, Vol. 83 Issue 2, p219
Academic Journal
The gastrointestinal tract is the largest endocrine organ in the body and it is connected through the vagal neurons with brainstem, which acts as a site of integration between endocrine and neuronal signals. Gut hormones function to optimize the process of digestion and absorbtion of nutrients by the gut. The most well studied in this regard are: cholecystokinin, pancreatic polypeptide, peptide YY, glukagon-like peptide-1, oxyntomodulin and ghrelin. Recent research suggests that gut hormones can be manipulated to regulate energy balance in humans. Gut hormone-based therapies may thus provide an effective and well-tolerated treatment for diabetes mellitus and obesity.


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