Single Stem Cell Theory Challenged
- The haematopoiesis transcription landscape. Le Bot, Nathalie // Nature Cell Biology;Jan2013, Vol. 15 Issue 1, p16
The article reports on a study which employed surface markers for the isolation of haematopoietic stem cells (HSCs) of embryos, and found that the HSCs that emerge from dorsal aorta exhibit gene expression profile that is close to macrophages'.
- Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Mayack, Shane R.; Shadrach, Jennifer L.; Kim, Francis S.; Wagers, Amy J. // Nature;10/14/2010, Vol. 467 Issue 7317, p872
The article announces that the article "Systemic signals regulate ageing and rejuvenation of blood stem cell niches," by Shane R. Mayack and colleagues has been retracted by three of its authors from the 2010 issue of the journal "Nature."
- Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion. Kent, David G.; Li, Juan; Tanna, Hinal; Fink, Juergen; Kirschner, Kristina; Pask, Dean C.; Silber, Yvonne; Hamilton, Tina L.; Sneade, Rachel; Simons, Benjamin D.; Green, Anthony R. // PLoS Biology;Jun2013, Vol. 11 Issue 6, p1
: In this study, single cell assays and mathematical modeling demonstrate that a single oncogenic point mutation can negatively affect hematopoietic stem cells while leaving progenitor cell expansion intact.
- Dynamic niches in the origination and differentiation of haematopoietic stem cells. Wang, Leo D.; Wagers, Amy J. // Nature Reviews Molecular Cell Biology;Oct2011, Vol. 12 Issue 10, p643
Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells. HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic 'niche', or...
- Improving Bone Marrow Transplants. // BioWorld Today;9/27/2010, Vol. 21 Issue 186, Special section p1
The article discusses research done on a molecular communication path that affects the mobilization of hematopoietic stem cells that could improve bone marrow transplants conducted by researchers at Cincinnati Children's Hospital Medical Center, published in "Nature Medicine."
- Inducible T-cell receptor expression in precursor T cells for leukemia control. Hoseini, S S; Hapke, M; Herbst, J; Wedekind, D; Baumann, R; Heinz, N; Schiedlmeier, B; Vignali, D A A; van den Brink, M R M; Schambach, A; Blazar, B R; Sauer, M G // Leukemia (08876924);Jul2015, Vol. 29 Issue 7, p1530
Co-transplantation of hematopoietic stem cells with those engineered to express leukemia-reactive T-cell receptors (TCRs) and differentiated ex vivo into precursor T cells (preTs) may reduce the risk of leukemia relapse. As expression of potentially self-(leukemia-) reactive TCRs will lead to...
- Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation. Suzuki, Nao; Yamazaki, Satoshi; Yamaguchi, Tomoyuki; Okabe, Motohito; Masaki, Hideki; Takaki, Satoshi; Otsu, Makoto; Nakauchi, Hiromitsu // Molecular Therapy;Jul2013, Vol. 21 Issue 7, p1424
In vitro generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) has the potential to provide novel therapeutic approaches for replacing bone marrow (BM) transplantation without rejection or graft versus host disease. Hitherto, however, it has proved difficult...
- Generation and Homing of iPSC-Derived Hematopoietic Cells In Vivo. Chou, Bin-Kuan; Ye, Zhaohui; Cheng, Linzhao // Molecular Therapy;Jul2013, Vol. 21 Issue 7, p1292
The author comments on the article "Generation of engraftable hematopoietic stem cells (HSC) from induced pluripotent stem cells (iPSC) by way of teratoma formation," by N. Suzuki et al. The iPSC-derived HSC-like cells were demonstrated to be existing within the teratoma as well as within the...
- Regeneration-associated WNT Signaling Is Activated in Long-term Reconstituting AC133bright Acute Myeloid Leukemia Cells. Beghini, Alessandro; Corlazzoli, Francesca; Del Giacco, Luca; Re, Matteo; Lazzaroni, Francesca; Brioschi, Matteo; Valentini, Giorgio; Ferrazzi, Fulvia; Ghilardi, Anna; Righi, Marco; Turrini, Mauro; Mignardi, Marco; Cesana, Clara; Bronte, Vincenzo; Nilsson, Mats; Morra, Enrica; Cairoli, Roberto // Neoplasia;Dec2012, Vol. 14 Issue 12, p1236
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by two molecularly distinct self-renewing leukemic stem cell (LSC) populations most closely related to normal progenitors and organized as a hierarchy. A requirement for WNT/ï¿½-catenin signaling in the...