TITLE

Feasibility of a PVDF Receiver for Monitoring of Transcranial Therapy

AUTHOR(S)
O'Reilly, Meaghan A.; Hynynen, Kullervo
PUB. DATE
March 2010
SOURCE
AIP Conference Proceedings;3/9/2010, Vol. 1215 Issue 1, p212
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An MRI compatible PVDF receiver was designed and manufactured for integration into a transcranial therapy array. 4.8 mm diameter, 110 μm thick PVDF film was air-backed by clamping it across brass tubing. A preamplifier was enclosed within the tubing to improve SNR and drive the long coaxial cables required to reach outside the MRI. The receiver was mounted inside a ring element from an existing array. The receiver performance was compared with a commercial needle hydrophone and tested for MRI compatibility. The PVDF receiver displayed a higher sensitivity than the needle hydrophone and a better capability to reject electrical coupling with the transmit element. MRI image artifacts created by the device were small, and diagnostic ultrasound was possible with the device while simultaneously obtaining an MRI image. Microbubble contrast agent was sonicated both directly, and through a fragment of human skull. The transmit/receive pair was successful in sonicating the microbubbles transcranially and detecting the returning microbubble emissions. A second generation receiver with a diameter of 2.4 mm was manufactured, without sacrificing sensitivity, to increase the field of view of the device. Future work will focus on developing a multi-element receiver array and its testing for brain treatment monitoring.
ACCESSION #
48428915

 

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